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Mitosene

The mitosenes are a class of organic chemicals based on a quinone-containing three-ring structure related to the two-ring core of the indolequinones. They are derived from the mitomycins by reduction and are the active alkylating agents responsible for the antitumor activity of the mitomycins.

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Jun 29, 2026
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Chemical structure of mitosene source ↗

The mitosenes are a class of organic chemicals based on a quinone-containing three-ring structure related to the two-ring core of the indolequinones. They are derived from the mitomycins by reduction and are the active alkylating agents responsible for the antitumor activity of the mitomycins.12

References

References

  1. Maliepaard, Marc; de Mol, Nico J.; Tomasz, Maria; Gargiulo, Dario; Janssen, Lambert H. M.; van Duynhoven, John P. M.; van Velzen, Ewoud J. J.; Verboom, Willem; Reinhoudt, David N. (1997). "Mitosene–DNA Adducts. Characterization of Two Major DNA Monoadducts Formed by 1,10-Bis(acetoxy)-7-methoxymitosene upon Reductive Activation". Biochemistry. 36 (30): 9211–9220. doi:10.1021/bi9700680. PMID 9230054.
  2. Iyengar, 1 Bhashyam S.; Remers, William A. (1985). "A comparison of mechanisms proposed for the conversion of mitomycins into mitosenes". J. Med. Chem. 28 (7): 963–967. doi:10.1021/jm00145a021. PMID 3925148.{{cite journal}}: CS1 maint: numeric names: authors list (link)