MIS18BP1

MIS18BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGX
Identifiers
Aliases	MIS18BP1, C14orf106, HSA242977, KNL2, M18BP1, MIS18 binding protein 1
External IDs	OMIM: 618139; MGI: 2145099; HomoloGene: 10147; GeneCards: MIS18BP1; OMA:MIS18BP1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	45,253,540 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	65,219,378 bp
RNA expression pattern
	Top expressed in
	monocyte; ; ventricular zone; ; testicle; ; epithelium of colon; ; tendon of biceps brachii; ; gonad; ; ganglionic eminence; ; buccal mucosa cell; ; Achilles tendon; ; rectum;
	Top expressed in
	genital tubercle; ; tail of embryo; ; abdominal wall; ; zygote; ; medial ganglionic eminence; ; primitive streak; ; maxillary prominence; ; renal corpuscle; ; oocyte; ; mandibular prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	chromosome; chromosome, centromeric region; nucleus; nucleoplasm;
Biological process	cell division; cell cycle; CENP-A containing chromatin assembly; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	55320
	217653
	ENSG00000129534
	ENSMUSG00000047534
	Q6P0N0
	Q80WQ8
	NM_018353
	NM_172578
	NP_060823
	NP_766166
	Wikidata
View/Edit Human	View/Edit Mouse

MIS18 binding protein 1 is a protein that in humans is encoded by the MIS18BP1 gene.⁵⁶⁷ The gene is also known as LKNL2, M18BP1, C14orf106, and HSA242977⁵. M18BP1 protein is an important component in the CENPA deposition pathway, and in most eukaryotes M18BP1 is necessary for chromosome segregation.

References

GRCh38: Ensembl release 89: ENSG00000129534 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000047534 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"MIS18 binding protein 1". Retrieved 2011-12-04.
Maddox PS, Hyndman F, Monen J, Oegema K, Desai A (Mar 2007). "Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin". J Cell Biol. 176 (6): 757–63. doi:10.1083/jcb.200701065. PMC 2064049. PMID 17339379.
Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M (Jan 2007). "Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1". Dev Cell. 12 (1): 17–30. doi:10.1016/j.devcel.2006.11.002. PMID 17199038.

Further reading

Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M (January 2007). "Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1". Dev. Cell. 12 (1): 17–30. doi:10.1016/j.devcel.2006.11.002. PMID 17199038.
Maddox PS, Hyndman F, Monen J, Oegema K, Desai A (March 2007). "Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin". J. Cell Biol. 176 (6): 757–63. doi:10.1083/jcb.200701065. PMC 2064049. PMID 17339379.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129534 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047534 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "MIS18 binding protein 1". Retrieved 2011-12-04.

[pmid17339379-6] Maddox PS, Hyndman F, Monen J, Oegema K, Desai A (Mar 2007). "Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin". J Cell Biol. 176 (6): 757–63. doi:10.1083/jcb.200701065. PMC 2064049. PMID 17339379.

[pmid17199038-7] Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M (Jan 2007). "Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1". Dev Cell. 12 (1): 17–30. doi:10.1016/j.devcel.2006.11.002. PMID 17199038.

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