MESP1

MESP1
Identifiers
Aliases	MESP1, bHLHc5, mesoderm posterior bHLH transcription factor 1
External IDs	OMIM: 608689; MGI: 107785; HomoloGene: 32039; GeneCards: MESP1; OMA:MESP1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	89,751,249 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,443,536 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; oocyte; ; testicle; ; nasal epithelium; ; secondary oocyte; ; prefrontal cortex; ; amygdala; ; cingulate gyrus; ; anterior cingulate cortex; ; muscle of thigh;
	Top expressed in
	seminiferous tubule; ; spermatocyte; ; spermatid; ; embryo; ; morula; ; epiblast; ; primitive streak; ; right ventricle; ; embryo; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	Notch signaling pathway; neurogenesis; cardiac ventricle formation; regulation of transcription, DNA-templated; lateral mesoderm development; positive regulation of hepatocyte differentiation; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; negative regulation of mesodermal cell fate specification; cardiac muscle cell differentiation; positive regulation of Notch signaling pathway involved in heart induction; cardiac vascular smooth muscle cell differentiation; signal transduction involved in regulation of gene expression; heart morphogenesis; transcription by RNA polymerase II; transcription, DNA-templated; sinus venosus morphogenesis; heart looping; positive regulation of transcription, DNA-templated; cardioblast migration; cardiac cell fate determination; multicellular organism development; gastrulation; embryonic heart tube morphogenesis; growth involved in heart morphogenesis; positive regulation of striated muscle cell differentiation; cardioblast migration to the midline involved in heart field formation; endothelial cell differentiation; sinoatrial node cell differentiation; negative regulation of endodermal cell fate specification; secondary heart field specification; cardiac atrium formation; negative regulation of transcription, DNA-templated; cardioblast anterior-lateral migration; mesodermal cell migration; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; mesoderm formation; somitogenesis; embryonic pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	55897
	17292
	ENSG00000166823
	ENSMUSG00000030544
	Q9BRJ9
	P97309
	NM_018670
	NM_008588
	NP_061140
	NP_032614
	Wikidata
View/Edit Human	View/Edit Mouse

Mesoderm posterior 1 homolog (mouse) is a protein that in humans is encoded by the MESP1 gene.⁵ MESP1 is a transcription factor that regulates cardiovascular progenitor specification.⁶

References

GRCh38: Ensembl release 89: ENSG00000166823 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030544 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Mesoderm posterior 1 homolog (mouse)".
Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, Kyba M, Blanpain C (July 2008). "Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification". Cell Stem Cell. 3 (1): 69–84. doi:10.1016/j.stem.2008.06.009. PMID 18593560.

Further reading

David R, Brenner C, Stieber J, Schwarz F, Brunner S, Vollmer M, Mentele E, Müller-Höcker J, Kitajima S, Lickert H, Rupp R, Franz WM (March 2008). "MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling". Nature Cell Biology. 10 (3): 338–45. doi:10.1038/ncb1696. PMID 18297060. S2CID 205286617.
Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ (August 2012). "Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors". Proceedings of the National Academy of Sciences of the United States of America. 109 (32): 13016–21. Bibcode:2012PNAS..10913016I. doi:10.1073/pnas.1120299109. PMC 3420197. PMID 22826236.
Saga Y, Hata N, Kobayashi S, Magnuson T, Seldin MF, Taketo MM (September 1996). "MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation". Development. 122 (9): 2769–78. doi:10.1242/dev.122.9.2769. PMID 8787751.
Haraguchi S, Kitajima S, Takagi A, Takeda H, Inoue T, Saga Y (October 2001). "Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development". Mechanisms of Development. 108 (1–2): 59–69. doi:10.1016/S0925-4773(01)00478-6. PMID 11578861.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166823 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030544 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mesoderm posterior 1 homolog (mouse)".

[6] Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, Kyba M, Blanpain C (July 2008). "Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification". Cell Stem Cell. 3 (1): 69–84. doi:10.1016/j.stem.2008.06.009. PMID 18593560.

1

2

3

4

5

6