MEIOSIN

MEIOSIN
Identifiers
Aliases	MEIOSIN, HMGDC, basic helix-loop-helix and HMG-box containing 1, meiosis initiator, BHMG1
External IDs	MGI: 3647482; GeneCards: MEIOSIN; OMA:MEIOSIN - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,764,541 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	18,852,293 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; gonad; ; right auricle of heart; ; mucosa of esophagus;
	Top expressed in
	embryo; ; testicle; ; zygote; ; epiblast; ; spermatid; ; genital tubercle; ; mesencephalon; ; neural tube; ; secondary oocyte; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein dimerization activity; DNA binding;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	388553
	243866
	ENSG00000237452
	ENSMUSG00000085601
	C9JSJ3
	A0A5K7RLP0
	NM_001310124
	NM_001370811; NM_001370812
	NP_001297053
	NP_001357740; NP_001357741
	Wikidata
View/Edit Human	View/Edit Mouse

Meiosis initiator protein is a protein that in humans is encoded by the MEIOSIN gene.

MEIOSIN is a germ cell-specific transcription factor that acts as a gatekeeper of meiotic initiation in mammals, directing the critical switch from mitotic to meiotic cell division. Expressed in response to retinoic acid signaling, MEIOSIN forms a functional complex with STRA8 to directly activate the transcription of essential meiotic genes. This regulatory mechanism governs the timely entry of both male and female germ cells into meiosis, underpinning the formation of haploid gametes necessary for sexual reproduction. Loss of MEIOSIN disrupts meiotic gene activation and leads to infertility due to failure of meiotic progression.⁵⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000237452 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000085601 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ishiguro KI, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, et al. (February 2020). "MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells". Developmental Cell. 52 (4): 429–445.e10. doi:10.1016/j.devcel.2020.01.010. PMID 32032549.
Oatley JM, Griswold MD (February 2020). "MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells". Developmental Cell. 52 (4): 397–398. doi:10.1016/j.devcel.2020.02.002. PMC 8555863. PMID 32097650.
Ishiguro KI, Shimada R (June 2022). "MEIOSIN directs initiation of meiosis and subsequent meiotic prophase program during spermatogenesis". Genes & Genetic Systems. 97 (1) 21-00054: 27–39. doi:10.1266/ggs.21-00054. PMID 34955498.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000237452 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000085601 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Ishiguro_2020-5] Ishiguro KI, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, et al. (February 2020). "MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells". Developmental Cell. 52 (4): 429–445.e10. doi:10.1016/j.devcel.2020.01.010. PMID 32032549.

[Oatley_2020-6] Oatley JM, Griswold MD (February 2020). "MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells". Developmental Cell. 52 (4): 397–398. doi:10.1016/j.devcel.2020.02.002. PMC 8555863. PMID 32097650.

[Ishiguro_2022-7] Ishiguro KI, Shimada R (June 2022). "MEIOSIN directs initiation of meiosis and subsequent meiotic prophase program during spermatogenesis". Genes & Genetic Systems. 97 (1) 21-00054: 27–39. doi:10.1266/ggs.21-00054. PMID 34955498.

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