MARCH6

MARCHF6
Identifiers
Aliases	MARCHF6, DOA10, MARCH-VI, RNF176, TEB4, membrane associated ring-CH-type finger 6, MARCH6, FAME3
External IDs	OMIM: 613297; MGI: 2442773; HomoloGene: 4301; GeneCards: MARCHF6; OMA:MARCHF6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	10,440,388 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	31,531,199 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; glutes; ; Region I of hippocampus proper; ; middle temporal gyrus; ; cerebellar vermis; ; dorsal motor nucleus of vagus nerve; ; corpus callosum; ; pons; ; postcentral gyrus;
	Top expressed in
	extensor digitorum longus muscle; ; cingulate gyrus; ; plantaris muscle; ; lateral septal nucleus; ; median eminence; ; ventromedial nucleus; ; subiculum; ; arcuate nucleus; ; amygdala; ; anterior amygdaloid area;
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme binding; ubiquitin-specific protease binding; zinc ion binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; transferase activity; protein binding;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; ER ubiquitin ligase complex; membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment;
Biological process	protein K48-linked ubiquitination; proteasomal protein catabolic process; ERAD pathway; protein ubiquitination; endoplasmic reticulum mannose trimming; ubiquitin-dependent ERAD pathway; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10299
	223455
	ENSG00000145495
	ENSMUSG00000039100
	O60337
	Q6ZQ89
	NM_001270660; NM_001270661; NM_005885
	NM_172606
	NP_001257589; NP_001257590; NP_005876
	NP_766194; NP_001389808
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase MARCH6 is an enzyme that in humans is encoded by the MARCH6 gene.⁵⁶

Gene name error in Excel

Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH6 gene in Microsoft Excel.⁷ This is due to Excel's autocorrect feature treating the text "MARCH6" as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error.⁸ The issue can be prevented by using an alias name (such as MARCHF6), prepending with an apostrophe ('), or preformatting the cell as text.

References

GRCh38: Ensembl release 89: ENSG00000145495 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000039100 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
"Entrez Gene: MARCH6 membrane-associated ring finger (C3HC4) 6".
Zeeberg BR, Riss J, Kane DW, Bussey KJ, Uchio E, Linehan WM, et al. (June 2004). "Mistaken identifiers: gene name errors can be introduced inadvertently when using Excel in bioinformatics". BMC Bioinformatics. 5 (1): 80. doi:10.1186/1471-2105-5-80. PMC 459209. PMID 15214961.
Ziemann M, Eren Y, El-Osta A (August 2016). "Gene name errors are widespread in the scientific literature". Genome Biology. 17 (1): 177. doi:10.1186/s13059-016-1044-7. PMC 4994289. PMID 27552985.

External links

MARCH6 human gene location in the UCSC Genome Browser.
MARCH6 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145495 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039100 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14722266-5] Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Fruh K (Jan 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.

[entrez-6] "Entrez Gene: MARCH6 membrane-associated ring finger (C3HC4) 6".

[ExcelAteMyDNA-7] Zeeberg BR, Riss J, Kane DW, Bussey KJ, Uchio E, Linehan WM, et al. (June 2004). "Mistaken identifiers: gene name errors can be introduced inadvertently when using Excel in bioinformatics". BMC Bioinformatics. 5 (1): 80. doi:10.1186/1471-2105-5-80. PMC 459209. PMID 15214961.

[8] Ziemann M, Eren Y, El-Osta A (August 2016). "Gene name errors are widespread in the scientific literature". Genome Biology. 17 (1): 177. doi:10.1186/s13059-016-1044-7. PMC 4994289. PMID 27552985.

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MARCH6

Gene name error in Excel

See also

References

Further reading

External links