MAPKAP1

MAPKAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VOQ
Identifiers
Aliases	MAPKAP1, JC310, MIP1, SIN1, SIN1b, SIN1g, mitogen-activated protein kinase associated protein 1, MAPK associated protein 1
External IDs	OMIM: 610558; MGI: 2444554; HomoloGene: 11473; GeneCards: MAPKAP1; OMA:MAPKAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	125,707,234 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	34,624,950 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; apex of heart; ; stromal cell of endometrium; ; oocyte; ; gastrocnemius muscle; ; secondary oocyte; ; right auricle of heart; ; left adrenal cortex; ; left ventricle; ; right adrenal cortex;
	Top expressed in
	zygote; ; genital tubercle; ; secondary oocyte; ; tail of embryo; ; spermatocyte; ; muscle of thigh; ; ventricular zone; ; interventricular septum; ; epithelium of lens; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidic acid binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein kinase binding; phosphatidylinositol-3,4,5-trisphosphate binding;
Cellular component	Golgi apparatus; membrane; plasma membrane; nucleoplasm; cytoplasmic vesicle; nucleus; cytosol; TORC2 complex; cytoplasm;
Biological process	substantia nigra development; negative regulation of Ras protein signal transduction; establishment or maintenance of actin cytoskeleton polarity; stress-activated protein kinase signaling cascade; TORC2 signaling; activation of protein kinase B activity; positive regulation of peptidyl-serine phosphorylation; regulation of cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	79109
	227743
	ENSG00000119487
	ENSMUSG00000038696
	Q9BPZ7
	Q8BKH7
NM_001006617; NM_001006618; NM_001006619; NM_001006620; NM_001006621;
	NM_024117
NM_001290625; NM_001290626; NM_177345; NM_001362919; NM_001362920;
	NM_001362921
NP_001006618; NP_001006619; NP_001006620; NP_001006621; NP_001006622;
	NP_077022
NP_001277554; NP_001277555; NP_796319; NP_001349848; NP_001349849;
	NP_001349850
	Wikidata
View/Edit Human	View/Edit Mouse

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.⁵⁶ As the name indicates, it is a subunit of mTOR complex 2.

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene.⁶

References

GRCh38: Ensembl release 89: ENSG00000119487 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038696 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Schroder W, Cloonan N, Bushell G, et al. (Sep 2004). "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene". Gene. 339: 17–23. doi:10.1016/j.gene.2004.07.001. PMID 15363842.
"Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1".

Further reading

Colicelli J, Nicolette C, Birchmeier C, et al. (1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2913–7. Bibcode:1991PNAS...88.2913C. doi:10.1073/pnas.88.7.2913. PMC 51350. PMID 1849280.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Schroder W, Bushell G, Sculley T (2005). "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins". Cell. Signal. 17 (6): 761–7. doi:10.1016/j.cellsig.2004.10.015. PMID 15722200.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Cheng J, Zhang D, Kim K, et al. (2005). "Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation". Mol. Cell. Biol. 25 (14): 5955–64. doi:10.1128/MCB.25.14.5955-5964.2005. PMC 1168836. PMID 15988011.
Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Frias MA, Thoreen CC, Jaffe JD, et al. (2006). "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s". Curr. Biol. 16 (18): 1865–70. Bibcode:2006CBio...16.1865F. doi:10.1016/j.cub.2006.08.001. PMID 16919458. S2CID 8239162.
Jacinto E, Facchinetti V, Liu D, et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell. 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. PMID 16962653. S2CID 230319.
Yang Q, Inoki K, Ikenoue T, et al. (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes Dev. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC 1619946. PMID 17043309.
Makino C, Sano Y, Shinagawa T, et al. (2007). "Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway". Genes Cells. 11 (11): 1239–51. doi:10.1111/j.1365-2443.2006.01016.x. PMID 17054722. S2CID 10605647.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Schroder WA, Buck M, Cloonan N, et al. (2007). "Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling". Cell. Signal. 19 (6): 1279–89. doi:10.1016/j.cellsig.2007.01.013. PMID 17303383.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119487 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038696 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15363842-5] Schroder W, Cloonan N, Bushell G, et al. (Sep 2004). "Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene". Gene. 339: 17–23. doi:10.1016/j.gene.2004.07.001. PMID 15363842.

[entrez-6] "Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1".

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