MAP3K7IP3

TAB3
Identifiers
Aliases	TAB3, MAP3K7IP3, NAP1, TGF-beta activated kinase 1/MAP3K7 binding protein 3, TGF-beta activated kinase 1 and MAP3K7 binding protein 3, TGF-beta activated kinase 1 (MAP3K7) binding protein 3
External IDs	OMIM: 300480; MGI: 1913974; HomoloGene: 17673; GeneCards: TAB3; OMA:TAB3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	30,975,084 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	85,634,469 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; pancreatic ductal cell; ; germinal epithelium; ; amniotic fluid; ; epithelium of nasopharynx; ; buccal mucosa cell; ; gingival epithelium; ; tail of epididymis; ; palpebral conjunctiva; ; visceral pleura;
	Top expressed in
	retinal pigment epithelium; ; ureter; ; facial motor nucleus; ; primitive streak; ; medullary collecting duct; ; blood; ; hair follicle; ; Paneth cell; ; fetal liver hematopoietic progenitor cell; ; sexually immature organism;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; protein binding;
Cellular component	cytosol; plasma membrane; endosome membrane; extracellular exosome;
Biological process	stimulatory C-type lectin receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; Fc-epsilon receptor signaling pathway; JNK cascade; positive regulation of NF-kappaB transcription factor activity; I-kappaB kinase/NF-kappaB signaling; negative regulation of autophagy; nucleotide-binding oligomerization domain containing signaling pathway; MyD88-independent toll-like receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	257397
	66724
	ENSG00000157625
	ENSMUSG00000035476
	Q8N5C8
	Q571K4
	NM_152787; NM_198312; NM_001399870; NM_001399872; NM_001399873
	NM_025729; NM_001358447
	NP_690000
	NP_080005; NP_001345376
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.⁵⁶⁷

Function

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.⁷

Interactions

MAP3K7IP3 has been shown to interact with MAP3K7IP2,⁵ TAB1⁶ and MAP3K7.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000157625 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035476 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Nov 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
"Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3".

Further reading

Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Jin G, Klika A, Callahan M, Faga B, Danzig J, Jiang Z, Li X, Stark GR, Harrington J, Sherf B (2004). "Identification of a human NF-kappaB-activating protein, TAB3". Proc. Natl. Acad. Sci. U.S.A. 101 (7): 2028–33. Bibcode:2004PNAS..101.2028J. doi:10.1073/pnas.0307314101. PMC 357046. PMID 14766965.
Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ (2004). "TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains". Mol. Cell. 15 (4): 535–48. doi:10.1016/j.molcel.2004.08.008. PMID 15327770.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H, Darnay BG (2007). "TAK1-dependent signaling requires functional interaction with TAB2/TAB3". J. Biol. Chem. 282 (6): 3918–28. doi:10.1074/jbc.M608867200. PMC 3197015. PMID 17158449.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035476 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14633987-5] Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Nov 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.

[pmid14670075-6] Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.

[entrez-7] "Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3".

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