Article · Wikipedia archive · Last revised Jun 19, 2026

Α-Mannosidase

α-Mannosidase is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase.

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Jun 19, 2026
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Cartoon depiction of the protein Streptococcus pyogenes family GH38 α-Mannosidase created using PyMol.12 source ↗
α-Mannosidase
α-Mannosidase 1, tetramer, Saccharomyces cerevisiae
Identifiers
EC no.3.2.1.24
CAS no.9025-42-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

α-Mannosidase (EC 3.2.1.24, α-D-mannosidase, p-nitrophenyl-α-mannosidase, α-D-mannopyranosidase, 1,2-α-mannosidase, 1,2-α-D-mannosidase, exo-α-mannosidase) is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase.34

Isoenzymes

Humans express the following three α-mannosidase isoenzymes:

mannosidase, α, class 2B, member 1
Identifiers
SymbolMAN2B1
Alt. symbolsMANB
NCBI gene4125
HGNC6826
OMIM609458
RefSeqNM_000528
UniProtO00754
Other data
EC number3.2.1.24
LocusChr. 19 cen-q13.1
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StructuresSwiss-model
DomainsInterPro
mannosidase, α, class 2B, member 2
Identifiers
SymbolMAN2B2
Alt. symbolsKIAA0935
NCBI gene23324
HGNC29623
RefSeqNM_015274
UniProtQ9Y2E5
Other data
EC number3.2.1.24
LocusChr. 4 p16.2
Search for
StructuresSwiss-model
DomainsInterPro
mannosidase, α, class 2C, member 1
Identifiers
SymbolMAN2C1
Alt. symbolsMANA1, MANA
NCBI gene4123
HGNC6827
OMIM154580
RefSeqNM_006715
UniProtQ9NTJ4
Other data
EC number3.2.1.24
LocusChr. 15 q11-qter
Search for
StructuresSwiss-model
DomainsInterPro

Applications

It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.5

Pathology

A deficiency can lead to α-mannosidosis.6

References

References

  1. "PyMol". Schrodinger. Retrieved 2011-09-14.
  2. Suits MD, Zhu Y, Taylor EJ, Walton J, Zechel DL, Gilbert HJ, et al. (February 2010). "Structure and kinetic investigation of Streptococcus pyogenes family GH38 alpha-mannosidase". PLOS ONE. 5 (2) e9006. Bibcode:2010PLoSO...5.9006S. doi:10.1371/journal.pone.0009006. PMC 2815779. PMID 20140249.
  3. Li YT (February 1966). "Presence of alpha-D-mannosidic linkage in glycoproteins. Liberation of d-mannose from various glycoproteins by alpha-mannosidase isolated from jack bean meal". The Journal of Biological Chemistry. 241 (4): 1010–1012. doi:10.1016/S0021-9258(18)96865-1. PMID 5905120.
  4. Winchester B (June 1984). "Role of alpha-D-mannosidases in the biosynthesis and catabolism of glycoproteins". Biochemical Society Transactions. 12 (3): 522–524. doi:10.1042/bst0120522. PMID 6428944.
  5. Vlahopoulos S, Gritzapis AD, Perez SA, Cacoullos N, Papamichail M, Baxevanis CN (July 2009). "Mannose addition by yeast Pichia Pastoris on recombinant HER-2 protein inhibits recognition by the monoclonal antibody herceptin". Vaccine. 27 (34): 4704–4708. doi:10.1016/j.vaccine.2009.05.063. PMID 19520203.
  6. Malm D, Nilssen Ø (July 2008). "Alpha-mannosidosis". Orphanet Journal of Rare Diseases. 3 21. doi:10.1186/1750-1172-3-21. PMC 2515294. PMID 18651971.
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