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Macrococcus caseolyticus

Macrococcus caseolyticus is a nonmotile, gram-positive cocci bacteria of the genus Macrococcus. They typically occur singly in pairs or short chains and clusters.

Last revised
Jul 13, 2026
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Macrococcus caseolyticus
Scientific classification Edit this classification
Domain: Bacteria
Kingdom: Bacillati
Phylum: Bacillota
Class: Bacilli
Order: Bacillales
Family: Staphylococcaceae
Genus: Macrococcus
Species:
M. caseolyticus
Binomial name
Macrococcus caseolyticus
Kloos et al., 1998

Macrococcus caseolyticus is a nonmotile, gram-positive cocci bacteria of the genus Macrococcus. They typically occur singly in pairs or short chains and clusters.1

M. caseolyticus are the most studied species in the genus Macrococcus. They have been used in the process of creating fermented foods, helping to develop flavor and aroma. They are commonly used as starter cultures in fermentation.2

They are nonpathogenic or opportunistic pathogens. Studies have shown that M. caseolyticus has genes associated with resistance to methicillin and other antibiotics in M. caseolytics and these resistance genes could be transferred into other bacteria in food, typically staphylococcal species.2

M. caseolyticus is phylogenetically related to Staphylococcus. It has a small chromosome of 2.1 MB and 8 plasmids.3

References

References

  1. Kloos, W. E.; Ballard, D. N.; George, C. G.; Webster, J. A.; Hubner, R. J.; Ludwig, W.; Schleifer, K. H.; Fiedler, F.; Schubert, K. (1998). "Delimiting the genus Staphylococcus through description of Macrococcus caseolyticus gen. nov., comb. Nov. And Macrococcus equipercicus sp. nov., and Macrococcus bovicus sp. no. And Macrococcus carouselicus sp. nov". International Journal of Systematic Bacteriology. 48 Pt 3: 859–877. doi:10.1099/00207713-48-3-859. PMID 9734040.
  2. Ramos GLPA; Vigoder, H. C.; Nascimento, J. S. (2021). "Technological Applications of Macrococcus caseolyticus and its Impact on Food Safety". Current Microbiology. 78 (1): 11–16. doi:10.1007/s00284-020-02281-z. PMID 33165661.
  3. Baba, T.; Kuwahara-Arai, K.; Uchiyama, I.; Takeuchi, F.; Ito, T.; Hiramatsu, K. (2009). "Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, corrected reflecting the ancestral genome of the human-pathogenic staphylococci". Journal of Bacteriology. 191 (4): 1180–1190. doi:10.1128/JB.01058-08. PMC 2632007. PMID 19074389.