Article · Wikipedia archive · Last revised Jul 13, 2026

LTBP3

Latent-transforming growth factor beta-binding protein 3 is a protein that in humans is encoded by the LTBP3 gene.

Last revised

Jul 13, 2026

Read time

≈ 3 min

Length

773 w

Citations

10

Source

LTBP3

Identifiers

LTBP3, LTBP-3, LTBP2, STHAG6, pp6425, DASS, latent transforming growth factor beta binding protein 3, GPHYSD3

External IDs

OMIM: 602090; MGI: 1101355; HomoloGene: 7405; GeneCards: LTBP3; OMA:LTBP3 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)¹

Band	11q13.1	Start	65,538,559 bp¹
Band	11q13.1	End	65,558,930 bp¹

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)²

Band	19 A\|19 4.34 cM	Start	5,790,932 bp²
Band	19 A\|19 4.34 cM	End	5,808,560 bp²

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Descending thoracic aorta

ascending aorta

right ovary

right coronary artery

left ovary

gastric mucosa

right uterine tube

body of uterus

stromal cell of endometrium

canal of the cervix

Top expressed in

ciliary body

ascending aorta

semi-lunar valve

external carotid artery

iris

aortic valve

vestibular membrane of cochlear duct

retinal pigment epithelium

tunica media of zone of aorta

internal carotid artery

More reference expression data


More reference expression data

Gene ontology
Molecular function	calcium ion binding transforming growth factor beta binding growth factor binding
Cellular component	extracellular matrix extracellular exosome extracellular region collagen-containing extracellular matrix
Biological process	transforming growth factor beta activation positive regulation of mesenchymal stem cell proliferation positive regulation of mesenchymal stem cell differentiation
Sources:Amigo / QuickGO

Species

Human

Mouse


4054


16998


ENSG00000168056


ENSMUSG00000024940


Q9NS15


Q61810

RefSeq (mRNA)


NM_001130144 NM_001164266 NM_021070


NM_008520

RefSeq (protein)


NP_001123616 NP_001157738 NP_066548


NP_032546

Location (UCSC)

Chr 11: 65.54 – 65.56 Mb

Chr 19: 5.79 – 5.81 Mb

PubMed search

³

⁴

View/Edit Human

View/Edit Mouse

Latent-transforming growth factor beta-binding protein 3 is a protein that in humans is encoded by the LTBP3 gene.⁵⁶

References

References

GRCh38: Ensembl release 89: ENSG00000168056 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024940 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Li X, Yin W, Perez-Jurado L, Bonadio J, Francke U (May 1995). "Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2)" (PDF). Mamm Genome. 6 (1): 42–5. doi:10.1007/BF00350892. hdl:2027.42/47013. PMID 7719025. S2CID 32672633.
"Entrez Gene: LTBP3 latent transforming growth factor beta binding protein 3".

Further reading

Further reading

Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J (2000). "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action". Cytokine Growth Factor Rev. 10 (2): 99–117. doi:10.1016/S1359-6101(99)00010-6. PMID 10743502.
Oklü R, Hesketh R (2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem. J. 352 Pt 3 (Pt 3): 601–10. doi:10.1042/0264-6021:3520601. PMC 1221494. PMID 11104663.
Morén A, Olofsson A, Stenman G, et al. (1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J. Biol. Chem. 269 (51): 32469–78. doi:10.1016/S0021-9258(18)31659-4. PMID 7798248.
Michel K, Roth S, Trautwein C, et al. (1998). "Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region". Hepatology. 27 (6): 1592–9. doi:10.1002/hep.510270619. PMID 9620332. S2CID 41314097.
Saharinen J, Keski-Oja J (2000). "Specific Sequence Motif of 8-Cys Repeats of TGF-β Binding Proteins, LTBPs, Creates a Hydrophobic Interaction Surface for Binding of Small Latent TGF-β". Mol. Biol. Cell. 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. PMC 14949. PMID 10930463.
Brooke JS, Cha JH, Eidels L (2002). "Latent transforming growth factor β-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor". BMC Cell Biol. 3: 2. doi:10.1186/1471-2121-3-2. PMC 65547. PMID 11846885.
Chen Y, Dabovic B, Annes JP, Rifkin DB (2002). "Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion". FEBS Lett. 517 (1–3): 277–80. Bibcode:2002FEBSL.517..277C. doi:10.1016/S0014-5793(02)02648-0. PMID 12062452. S2CID 83982805.
Penttinen C, Saharinen J, Weikkolainen K, et al. (2003). "Secretion of human latent TGF-beta-binding protein-3 (LTBP-3) is dependent on co-expression of TGF-beta". J. Cell Sci. 115 (Pt 17): 3457–68. doi:10.1242/jcs.115.17.3457. PMID 12154076.
Ludbrook SB, Barry ST, Delves CJ, Horgan CM (2003). "The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3". Biochem. J. 369 (Pt 2): 311–8. doi:10.1042/BJ20020809. PMC 1223078. PMID 12358597.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Koli K, Hyytiäinen M, Ryynänen MJ, Keski-Oja J (2005). "Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts". Exp. Cell Res. 310 (2): 370–82. doi:10.1016/j.yexcr.2005.08.008. PMID 16157329.
Kantola AK, Keski-Oja J, Koli K (2006). "Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements". Gene. 363: 142–50. doi:10.1016/j.gene.2005.07.042. PMID 16223572.