Leukotriene B4

Leukotriene B₄
	source ↗
Names
	Preferred IUPAC name (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid
Identifiers
CAS Number	71160-24-2 Y;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:15647 Y;
ChEMBL	ChEMBL65061 Y;
ChemSpider	4444132 Y;
IUPHAR/BPS	2487;
KEGG	C02165 Y;
PubChem CID	5280492;
UNII	1HGW4DR56D Y;
CompTox Dashboard (EPA)	DTXSID4037162 ;
	InChI InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 Y Key: VNYSSYRCGWBHLG-AMOLWHMGSA-N Y;
	SMILES CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O;
Properties
Chemical formula	C20H32O4
Molar mass	336.472 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Leukotriene B₄ (LTB₄) is a leukotriene involved in inflammation. It has been shown to promote insulin resistance in obese mice.

Biochemistry

LTB₄ is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue.¹ In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosomal enzymes by these cells.¹ It is synthesized by leukotriene-A4 hydrolase from leukotriene A₄.²

Eicosanoid synthesis (leukotrienes at right) source ↗

Diabetes

A study at the University of California, San Diego School of Medicine has shown that LTB₄ promotes insulin resistance in obese mice.³ Obesity is the major cause of insulin resistance in type 2 diabetes.⁴

References

Cotran; Kumar, Collins (1999). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.
"LTA4H". uniprot. Retrieved 9 April 2013.
"Molecular Link between Obesity and Type 2 Diabetes Reveals Potential Therapy". UC San Diego Health. Archived from the original on 2022-02-18.
Li, P; Oh, DY; Bandyopadhyay, G; Lagakos, WS; Talukdar, S; Osborn, O; Johnson, A; Chung, H; Maris, M; Ofrecio, JM; Taguchi, S; Lu, M; Olefsky, JM (2015). "LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes". Nature Medicine. 21 (3): 239–247. doi:10.1038/nm.3800. PMC 4429798. PMID 25706874.

[robspath-1] Cotran; Kumar, Collins (1999). Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. ISBN 0-7216-7335-X.

[P09960-2] "LTA4H". uniprot. Retrieved 9 April 2013.

[3] "Molecular Link between Obesity and Type 2 Diabetes Reveals Potential Therapy". UC San Diego Health. Archived from the original on 2022-02-18.

[4] Li, P; Oh, DY; Bandyopadhyay, G; Lagakos, WS; Talukdar, S; Osborn, O; Johnson, A; Chung, H; Maris, M; Ofrecio, JM; Taguchi, S; Lu, M; Olefsky, JM (2015). "LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes". Nature Medicine. 21 (3): 239–247. doi:10.1038/nm.3800. PMC 4429798. PMID 25706874.

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