LRRN2

LRRN2
Identifiers
Aliases	LRRN2, FIGLER7, GAC1, LRANK1, LRRN5, leucine rich repeat neuronal 2
External IDs	OMIM: 605492; MGI: 106037; HomoloGene: 21274; GeneCards: LRRN2; OMA:LRRN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	204,685,738 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	132,867,743 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Region I of hippocampus proper; ; Brodmann area 10; ; Epithelium of choroid plexus; ; ventricular zone; ; nucleus accumbens; ; anterior pituitary; ; cingulate gyrus; ; anterior cingulate cortex; ; ganglionic eminence;
	Top expressed in
	lateral geniculate nucleus; ; medial dorsal nucleus; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; medial geniculate nucleus; ; primary visual cortex; ; anterior amygdaloid area; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor activity;
Cellular component	integral component of membrane; membrane; extracellular space; extracellular matrix;
Biological process	cell adhesion; axonogenesis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	10446
	16980
	ENSG00000170382
	ENSMUSG00000026443
	O75325
	Q6PHP6
	NM_006338; NM_201630
	NM_010732
	NP_006329; NP_963924
	NP_034862
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat neuronal protein 2 is a protein that in humans is encoded by the LRRN2 gene.⁵⁶

The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.⁶

References

GRCh38: Ensembl release 89: ENSG00000170382 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026443 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Almeida A, Zhu XX, Vogt N, Tyagi R, Muleris M, Dutrillaux AM, Dutrillaux B, Ross D, Malfoy B, Hanash S (Aug 1998). "GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas". Oncogene. 16 (23): 2997–3002. doi:10.1038/sj.onc.1201828. PMID 9662332.
"Entrez Gene: LRRN2 leucine rich repeat neuronal 2".

Further reading

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Adams MD, Soares MB, Kerlavage AR, et al. (1993). "Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library". Nat. Genet. 4 (4): 373–80. doi:10.1038/ng0893-373. PMID 8401585. S2CID 12612300.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170382 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026443 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9662332-5] Almeida A, Zhu XX, Vogt N, Tyagi R, Muleris M, Dutrillaux AM, Dutrillaux B, Ross D, Malfoy B, Hanash S (Aug 1998). "GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas". Oncogene. 16 (23): 2997–3002. doi:10.1038/sj.onc.1201828. PMID 9662332.

[entrez-6] "Entrez Gene: LRRN2 leucine rich repeat neuronal 2".

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