Latrophilin 3

ADGRL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5CMN, 5AFB
Identifiers
Aliases	ADGRL3, CIRL3, LEC3, CL3, LPHN3, adhesion G protein-coupled receptor L3
External IDs	OMIM: 616417; MGI: 2441950; HomoloGene: 22878; GeneCards: ADGRL3; OMA:ADGRL3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	62,078,335 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	81,825,133 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; saphenous vein; ; middle temporal gyrus; ; endothelial cell; ; entorhinal cortex; ; pars compacta; ; superior vestibular nucleus; ; orbitofrontal cortex; ; Achilles tendon; ; Brodmann area 23;
	Top expressed in
	Region I of hippocampus proper; ; otolith organ; ; utricle; ; ventromedial nucleus; ; substantia nigra; ; anterior amygdaloid area; ; lateral septal nucleus; ; lateral hypothalamus; ; medial geniculate nucleus; ; olfactory tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; metal ion binding; protein binding; transmembrane signaling receptor activity; carbohydrate binding; calcium ion binding;
Cellular component	integral component of membrane; cell projection; membrane; cell-cell junction; plasma membrane; axon; cell junction; integral component of plasma membrane; glutamatergic synapse; intracellular anatomical structure;
Biological process	response to cocaine; G protein-coupled receptor signaling pathway; neuron migration; cell surface receptor signaling pathway; synapse assembly; locomotion involved in locomotory behavior; signal transduction; positive regulation of synapse assembly; cell-cell adhesion via plasma-membrane adhesion molecules; synapse organization; adenylate cyclase-activating G protein-coupled receptor signaling pathway; brain development;
	Sources:Amigo / QuickGO
Orthologs
	23284
	319387
	ENSG00000150471
	ENSMUSG00000037605
	Q9HAR2
	Q80TS3
NM_015236; NM_001322246; NM_001322402; NM_001371342; NM_001371343;
	NM_001371344; NM_001371345; NM_001371346
NM_198702; NM_001347367; NM_001347368; NM_001347369; NM_001347371;
	NM_001359826; NM_001359828; NM_001359829; NM_001359830; NM_001359831; NM_001359832; NM_001359833; NM_001359834
NP_001309175; NP_001309331; NP_056051; NP_001358271; NP_001358272;
	NP_001358273; NP_001358274; NP_001358275
NP_001334296; NP_001334297; NP_001334298; NP_001334300; NP_941991;
	NP_001346755; NP_001346757; NP_001346758; NP_001346759; NP_001346760; NP_001346761; NP_001346762; NP_001346763
	Wikidata
View/Edit Human	View/Edit Mouse

Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.⁵⁶

Function

This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.⁶

Clinical significance

A version of this gene has been linked to attention deficit hyperactivity disorder (ADHD).⁷

References

GRCh38: Ensembl release 89: ENSG00000150471 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037605 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–131. doi:10.3109/10799890009150640. PMID 10994649. S2CID 19919738.
"LPHN3 latrophilin 3". Entrez Gene. U.S. National Library of Medicine.
Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, et al. (November 2010). "A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication". Molecular Psychiatry. 15 (11): 1053–1066. doi:10.1038/mp.2010.6. hdl:11336/80502. PMID 20157310.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Adhesion G protein-coupled receptor L3
PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L3

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150471 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037605 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10994649-5] Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–131. doi:10.3109/10799890009150640. PMID 10994649. S2CID 19919738.

[entrez-6] "LPHN3 latrophilin 3". Entrez Gene. U.S. National Library of Medicine.

[pmid20157310-7] Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, et al. (November 2010). "A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication". Molecular Psychiatry. 15 (11): 1053–1066. doi:10.1038/mp.2010.6. hdl:11336/80502. PMID 20157310.

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Latrophilin 3

Function

Clinical significance

See also

References

Further reading

External links