 | |
 | |
| Combination of | |
|---|---|
| Amlodipine | Calcium channel blocker |
| Benazepril | ACE inhibitor |
| Clinical data | |
| Trade names | Lotrel |
| AHFS/Drugs.com | Professional Drug Facts |
| License data | |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider |
|
| KEGG | |
| CompTox Dashboard (EPA) | |
 N Y (what is this?) (verify) | |
Amlodipine/benazepril, sold under the brand name Lotrel among others, is a fixed-dose combination medication used to treat high blood pressure.1 It is a combination of amlodipine, as the besilate, a calcium channel blocker, and benazepril, an angiotensin converting enzyme inhibitor.1 It may be used if a single agent is not sufficient.1 It is taken by mouth.1
Common side effects include cough, dizziness, and swelling.1 Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure.1 Use in pregnancy is not recommended.1 Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.1
The combination was approved for medical use in the United States in 1995.2 It is available as a generic medication.3 In 2023, it was the 186th most commonly prescribed medication in the United States, with more than 2 million prescriptions.45
Medical uses
It is used to treat high blood pressure.1 It is not a first-line treatment.6
References
References
- "Lotrel- amlodipine besylate and benazepril hydrochloride capsule". DailyMed. U.S. National Library of Medicine. Retrieved 20 June 2021.
- Cerner Multum. "Amlodipine and benazepril Uses, Side Effects & Warnings". Drugs.com. Retrieved 10 March 2019.
- Bope ET, Kellerman RD (2016). Conn's Current Therapy 2017 E-Book. Elsevier Health Sciences. p. 124. ISBN 978-0-323-44335-7.
- "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
- "Amlodipine; Benazepril Drug Usage Statistics, United States, 2014 - 2023". ClinCalc. Retrieved 19 August 2025.
- Faulkner MA, Hilleman DE (January 2001). "Amlodipine/benazepril: fixed dose combination therapy for hypertension". Expert Opinion on Pharmacotherapy. 2 (1): 165–178. doi:10.1517/14656566.2.1.165. PMID 11336577. S2CID 23021242.