LNX1

LNX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B76
Identifiers
Aliases	LNX1, LNX, MPDZ, PDZRN2, ligand of numb-protein X 1
External IDs	OMIM: 609732; MGI: 1278335; HomoloGene: 7819; GeneCards: LNX1; OMA:LNX1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	53,701,405 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	74,863,573 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; parotid gland; ; Brodmann area 23; ; endothelial cell; ; Brodmann area 46; ; oral cavity; ; amniotic fluid; ; skin of arm; ; superior frontal gyrus; ; jejunal mucosa;
	Top expressed in
	motor neuron; ; facial motor nucleus; ; substantia nigra; ; vestibular membrane of cochlear duct; ; Paneth cell; ; right ventricle; ; epithelium of stomach; ; lacrimal gland; ; transitional epithelium of urinary bladder; ; anterior horn of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	PDZ domain binding; protein binding; metal ion binding; ubiquitin-protein transferase activity; transferase activity; zinc ion binding;
Cellular component	cytoplasm;
Biological process	protein homooligomerization; protein ubiquitination; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	84708
	16924
	ENSG00000072201
	ENSMUSG00000029228
	Q8TBB1
	O70263
	NM_001126328; NM_032622
NM_001159577; NM_001159578; NM_001159579; NM_001159580; NM_010727;
	NM_001359074
	NP_001119800; NP_116011
NP_001153049; NP_001153050; NP_001153051; NP_001153052; NP_034857;
	NP_001346003
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase LNX is an enzyme that in humans is encoded by the LNX1 gene.⁵⁶⁷

Interactions

LNX1 has been shown to interact with NAGK,⁸ NUMB⁶ and PAFAH1B3.⁸

References

GRCh38: Ensembl release 89: ENSG00000072201 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029228 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Xie Y, Zhao W, Wang W, Zhao S, Tang R, Ying K, Zhou Z, Mao Y (Apr 2001). "Identification of a human LNX protein containing multiple PDZ domains". Biochemical Genetics. 39 (3–4): 117–26. doi:10.1023/A:1010269908398. PMID 11521506. S2CID 9150813.
Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ (Jan 2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation". The EMBO Journal. 21 (1–2): 93–102. doi:10.1093/emboj/21.1.93. PMC 125803. PMID 11782429.
"Entrez Gene: LNX1 ligand of numb-protein X 1".
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

Dho SE, Jacob S, Wolting CD, French MB, Rohrschneider LR, McGlade CJ (Apr 1998). "The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX". The Journal of Biological Chemistry. 273 (15): 9179–87. doi:10.1074/jbc.273.15.9179. PMID 9535908.
Rice DS, Northcutt GM, Kurschner C (Nov 2001). "The Lnx family proteins function as molecular scaffolds for Numb family proteins". Molecular and Cellular Neurosciences. 18 (5): 525–40. doi:10.1006/mcne.2001.1024. PMID 11922143. S2CID 6021682.
Sollerbrant K, Raschperger E, Mirza M, Engstrom U, Philipson L, Ljungdahl PO, Pettersson RF (Feb 2003). "The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)". The Journal of Biological Chemistry. 278 (9): 7439–44. doi:10.1074/jbc.M205927200. PMID 12468544.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Katoh M, Katoh M (Apr 2004). "Identification and characterization of PDZRN3 and PDZRN4 genes in silico". International Journal of Molecular Medicine. 13 (4): 607–13. doi:10.3892/ijmm.13.4.607. PMID 15010864.
Armbruester V, Sauter M, Roemer K, Best B, Hahn S, Nty A, Schmid A, Philipp S, Mueller A, Mueller-Lantzsch N (Oct 2004). "Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X". Journal of Virology. 78 (19): 10310–9. doi:10.1128/JVI.78.19.10310-10319.2004. PMC 516385. PMID 15367597.
Chen J, Xu J, Zhao W, Hu G, Cheng H, Kang Y, Xie Y, Lu Y (Nov 2005). "Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas". The International Journal of Biochemistry & Cell Biology. 37 (11): 2273–83. doi:10.1016/j.biocel.2005.02.028. PMID 16002321.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Weiss A, Baumgartner M, Radziwill G, Dennler J, Moelling K (Oct 2007). "c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1". FEBS Letters. 581 (26): 5131–6. doi:10.1016/j.febslet.2007.09.062. PMID 17936276. S2CID 43098921.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072201 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029228 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11521506-5] Xie Y, Zhao W, Wang W, Zhao S, Tang R, Ying K, Zhou Z, Mao Y (Apr 2001). "Identification of a human LNX protein containing multiple PDZ domains". Biochemical Genetics. 39 (3–4): 117–26. doi:10.1023/A:1010269908398. PMID 11521506. S2CID 9150813.

[pmid11782429-6] Nie J, McGill MA, Dermer M, Dho SE, Wolting CD, McGlade CJ (Jan 2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation". The EMBO Journal. 21 (1–2): 93–102. doi:10.1093/emboj/21.1.93. PMC 125803. PMID 11782429.

[entrez-7] "Entrez Gene: LNX1 ligand of numb-protein X 1".

[pmid16189514-8] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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