LMO3

LMO3
Identifiers
Aliases	LMO3, RBTN3, RBTNL2, RHOM3, Rhom-3, LIM domain only 3
External IDs	OMIM: 180386; MGI: 102810; HomoloGene: 136507; GeneCards: LMO3; OMA:LMO3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	16,610,594 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	138,558,966 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 46; ; Brodmann area 23; ; orbitofrontal cortex; ; superior frontal gyrus; ; entorhinal cortex; ; endothelial cell; ; postcentral gyrus; ; optic nerve; ; nucleus accumbens;
	Top expressed in
	piriform cortex; ; Region I of hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; amygdala; ; hippocampus proper; ; lumbar subsegment of spinal cord; ; dorsal striatum; ; primary visual cortex; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	cytoplasm;
Biological process	negative regulation of ERK1 and ERK2 cascade; regulation of transcription, DNA-templated; positive regulation of fat cell differentiation; positive regulation of glucocorticoid receptor signaling pathway; transcription, DNA-templated; positive regulation of peroxisome proliferator activated receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	55885
	109593
	ENSG00000048540
	ENSMUSG00000030226
	Q8TAP4
	Q8BZL8
NM_001001395; NM_001243609; NM_001243610; NM_001243611; NM_001243612;
	NM_001243613; NM_018640
	NM_207222; NM_001356305; NM_001356306; NM_001356307
NP_001001395; NP_001230538; NP_001230539; NP_001230540; NP_001230541;
	NP_001230542; NP_061110
	NP_997105; NP_001343234; NP_001343235; NP_001343236
	Wikidata
View/Edit Human	View/Edit Mouse

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene.⁵⁶⁷ LMO3 interacts with the tumor suppressor p53 and regulates its function.⁸ LMO3 is considered to be an oncogene in Neuroblastoma.⁹

References

GRCh38: Ensembl release 89: ENSG00000048540 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030226 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
Shi J, Cai W, Chen X, Ying K, Zhang K, Xie Y (August 2001). "Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization". Brain Research. 910 (1–2): 29–37. doi:10.1016/S0006-8993(01)02393-9. PMID 11489251. S2CID 43814085.
EntrezGene 55885
Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.

Further reading

Friedel S, Saar K, Sauer S, Dempfle A, Walitza S, Renner T, Romanos M, Freitag C, et al. (October 2007). "Association and linkage of allelic variants of the dopamine transporter gene in ADHD". Molecular Psychiatry. 12 (10): 923–33. doi:10.1038/sj.mp.4001986. PMID 17579611.
Davis C, Levitan RD, Kaplan AS, Carter J, Reid C, Curtis C, Patte K, Kennedy JL (October 2007). "Dopamine transporter gene (DAT1) associated with appetite suppression to methylphenidate in a case-control study of binge eating disorder". Neuropsychopharmacology. 32 (10): 2199–206. doi:10.1038/sj.npp.1301348. PMID 17314918.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira M, et al. (June 2005). "LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma". Cancer Research. 65 (11): 4587–97. doi:10.1158/0008-5472.CAN-04-4630. PMID 15930276.
Foroni L, Boehm T, White L, Forster A, Sherrington P, Liao XB, Brannan CI, Jenkins NA, et al. (August 1992). "The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development". Journal of Molecular Biology. 226 (3): 747–61. doi:10.1016/0022-2836(92)90630-3. PMID 1507224.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000048540 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030226 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.

[pmid11489251-6] Shi J, Cai W, Chen X, Ying K, Zhang K, Xie Y (August 2001). "Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization". Brain Research. 910 (1–2): 29–37. doi:10.1016/S0006-8993(01)02393-9. PMID 11489251. S2CID 43814085.

[entrez-7] EntrezGene 55885

[8] Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.

[9] Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.

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