LGR6

LGR6
Identifiers
Aliases	LGR6, GPCR, VTS20631, leucine-rich repeat containing G protein-coupled receptor 6, leucine rich repeat containing G protein-coupled receptor 6
External IDs	OMIM: 606653; MGI: 2441805; HomoloGene: 49680; GeneCards: LGR6; OMA:LGR6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,319,781 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	135,033,014 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; left coronary artery; ; granulocyte; ; cardiac muscle tissue of right atrium; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; anterior pituitary;
	Top expressed in
	ascending aorta; ; aortic valve; ; skin of external ear; ; molar; ; secondary oocyte; ; right ventricle; ; median eminence; ; primary oocyte; ; skin of back; ; epidermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity; protein-hormone receptor activity; heparin binding; Roundabout binding;
Cellular component	integral component of membrane; vesicle; plasma membrane; integral component of plasma membrane; trans-Golgi network membrane; membrane; extracellular space;
Biological process	positive regulation of canonical Wnt signaling pathway; positive regulation of Wnt signaling pathway; G protein-coupled receptor signaling pathway; Wnt signaling pathway; signal transduction; positive regulation of cell migration; tissue regeneration; bone regeneration; axon guidance; negative chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	59352
	329252
	ENSG00000133067
	ENSMUSG00000042793
	Q9HBX8
	Q3UVD5
	NM_001017403; NM_001017404; NM_021636
	NM_001033409
	NP_001017403; NP_001017404; NP_067649
	NP_001028581
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene.⁵⁶ Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo.⁷

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.⁶

References

GRCh38: Ensembl release 89: ENSG00000133067 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042793 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol Endocrinol. 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549.
"Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6".
Huang, Phillips Y.; Kandyba, Eve; Jabouille, Arnaud; Sjolund, Jonas; Kumar, Atul; Halliwill, Kyle; McCreery, Melissa; DelRosario, Reyno; Kang, Hio Chung (2017). "Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma". Nature Genetics. 49 (11): 1624–1632. doi:10.1038/ng.3957. PMC 5662105. PMID 28945253.

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133067 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042793 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10935549-5] Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol Endocrinol. 14 (8): 1257–71. doi:10.1210/me.14.8.1257. PMID 10935549.

[entrez-6] "Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6".

[7] Huang, Phillips Y.; Kandyba, Eve; Jabouille, Arnaud; Sjolund, Jonas; Kumar, Atul; Halliwill, Kyle; McCreery, Melissa; DelRosario, Reyno; Kang, Hio Chung (2017). "Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma". Nature Genetics. 49 (11): 1624–1632. doi:10.1038/ng.3957. PMC 5662105. PMID 28945253.

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