LBX1

LBX1
Identifiers
Aliases	LBX1, HPX-6, HPX6, LBX1H, homeobox, ladybird homeobox 1, CCHS3
External IDs	OMIM: 604255; MGI: 104867; HomoloGene: 4784; GeneCards: LBX1; OMA:LBX1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	101,229,463 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	45,224,251 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; testicle; ; skeletal muscle tissue; ; right hemisphere of cerebellum; ; C1 segment; ; right lung; ; frontal lobe; ; Cortex of frontal lobe; ; dorsolateral prefrontal cortex;
	Top expressed in
	triceps brachii muscle; ; muscle of thigh; ; lumbar subsegment of spinal cord; ; ankle; ; vastus lateralis muscle; ; gastrocnemius muscle; ; tibialis anterior muscle; ; skeletal muscle tissue; ; zygote; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; transcription regulator complex;
Biological process	multicellular organism development; heart looping; anatomical structure morphogenesis; cell differentiation; muscle organ development; neuron fate commitment; spinal cord motor neuron differentiation; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; neuron fate determination; transcription, DNA-templated; nervous system development; negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	10660
	16814
	ENSG00000138136
	ENSMUSG00000025216
	P52954
	P52955
	NM_006562
	NM_010691
	NP_006553
	NP_034821
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene.⁵⁶

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes.

In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.⁶

References

GRCh38: Ensembl release 89: ENSG00000138136 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025216 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jagla K, Dolle P, Mattei MG, Jagla T, Schuhbaur B, Dretzen G, Bellard F, Bellard M (Jul 1996). "Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes". Mech Dev. 53 (3): 345–56. doi:10.1016/0925-4773(95)00450-5. PMID 8645601. S2CID 19021832.
"Entrez Gene: LBX1 ladybird homeobox 1".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
de Mollerat XJ, Gurrieri F, Morgan CT, et al. (2004). "A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24". Hum. Mol. Genet. 12 (16): 1959–71. doi:10.1093/hmg/ddg212. PMID 12913067.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kozmik Z, Holland LZ, Schubert M, et al. (2001). "Characterization of Amphioxus AmphiVent, an evolutionarily conserved marker for chordate ventral mesoderm". Genesis. 29 (4): 172–9. doi:10.1002/gene.1021. PMID 11309850. S2CID 7730828.
Moretti P, Simmons P, Thomas P, et al. (1994). "Identification of homeobox genes expressed in human haemopoietic progenitor cells". Gene. 144 (2): 213–9. doi:10.1016/0378-1119(94)90380-8. PMID 7518789.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138136 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025216 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8645601-5] Jagla K, Dolle P, Mattei MG, Jagla T, Schuhbaur B, Dretzen G, Bellard F, Bellard M (Jul 1996). "Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes". Mech Dev. 53 (3): 345–56. doi:10.1016/0925-4773(95)00450-5. PMID 8645601. S2CID 19021832.

[entrez-6] "Entrez Gene: LBX1 ladybird homeobox 1".

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