KRT36

KRT36
Identifiers
Aliases	KRT36, HA6, KRTHA6, hHa6, keratin 36
External IDs	OMIM: 604540; MGI: 109364; HomoloGene: 88459; GeneCards: KRT36; OMA:KRT36 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,492,546 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,996,452 bp
RNA expression pattern
	Top expressed in
	testicle; ; body of tongue; ; superior surface of tongue; ; mucosa of esophagus; ; spleen; ; cervix; ; lymph node; ; skin of limb; ; skin of leg; ; granulocyte;
	Top expressed in
	lip; ; hair follicle; ; embryo; ; skin of external ear; ; skin of back; ; tongue; ; filiform papilla; ; skin of abdomen; ; mammary gland; ; oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; structural constituent of skin epidermis;
Cellular component	intermediate filament cytoskeleton; extracellular exosome; intermediate filament; cytosol;
Biological process	regulation of keratinocyte differentiation; keratinization; cornification; biological process;
	Sources:Amigo / QuickGO
Orthologs
	8689
	16673
	ENSG00000126337
	ENSMUSG00000020916
	O76013
	B1AQ75
	NM_003771
	NM_001174099; NM_008472
	NP_003762
	NP_001167570
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cuticular Ha6 is a protein that in humans is encoded by the KRT36 gene.⁵⁶⁷

The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.⁷

References

GRCh38: Ensembl release 89: ENSG00000126337 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020916 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
"Entrez Gene: KRT36 keratin 36".

Further reading

Fuchs E, Weber K (1994). "Intermediate filaments: structure, dynamics, function, and disease". Annu. Rev. Biochem. 63: 345–82. doi:10.1146/annurev.bi.63.070194.002021. PMID 7979242.
Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.