Keratin 34

KRT34
Identifiers
Aliases	KRT34, HA4, Ha-4, KRTHA4, hHa4, Keratin 34, K34
External IDs	OMIM: 602763; MGI: 1309994; HomoloGene: 31083; GeneCards: KRT34; OMA:KRT34 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,382,306 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	99,932,380 bp
RNA expression pattern
	Top expressed in
	testicle; ; stromal cell of endometrium; ; placenta; ; skin of abdomen; ; ectocervix; ; skin of leg; ; vagina; ; canal of the cervix; ; right lung; ; mucosa of esophagus;
	Top expressed in
	lip; ; skin of back; ; hair follicle; ; skin of abdomen; ; dermis; ; skin of external ear; ; sexually immature organism; ; conjunctival fornix; ; medial head of gastrocnemius muscle; ; foregut;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity;
Cellular component	intermediate filament; extracellular exosome; extracellular space; cytosol;
Biological process	epidermis development; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3885
	16672
	ENSG00000131737; ENSG00000262045
	ENSMUSG00000043485
	O76011
	Q9D646
	NM_021013; NM_001386014
	NM_027563
	NP_066293
	NP_081839
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.⁵⁶⁷⁸

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q21.2 and have the same direction of transcription.⁸

References

ENSG00000262045 GRCh38: Ensembl release 89: ENSG00000131737, ENSG00000262045 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000043485 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Heid HW, Werner E, Franke WW (Feb 1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins". Differentiation. 32 (2): 101–19. doi:10.1111/j.1432-0436.1986.tb00562.x. PMID 2431943.
Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
"Entrez Gene: KRT34 keratin 34".

Further reading

Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Raica M, Zylis D, Cîmpean AM (2007). "Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma". Romanian Journal of Morphology and Embryology. 46 (1): 11–5. PMID 16286979.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.