KLF8

KLF8
Identifiers
Aliases	KLF8, BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8
External IDs	OMIM: 300286; MGI: 2442430; HomoloGene: 68549; GeneCards: KLF8; OMA:KLF8 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	56,291,531 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	152,179,128 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; oral cavity; ; skin of leg; ; vagina; ; skin of thigh; ; popliteal artery; ; tibial arteries; ; skin of hip; ; parietal pleura; ; gingival epithelium;
	Top expressed in
	placenta; ; morula; ; ganglionic eminence; ; epiblast; ; blastocyst; ; embryo; ; granulocyte; ; yolk sac; ; mesencephalon; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; metal ion binding; nucleic acid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol; aggresome;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	11279
	245671
	ENSG00000102349
	ENSMUSG00000041649
	O95600
	Q8BLM0
NM_001159296; NM_007250; NM_001324099; NM_001324100; NM_001324102;
	NM_001324104; NM_001324105
	NM_173780; NM_001357183
NP_001152768; NP_001311028; NP_001311029; NP_001311031; NP_001311033;
	NP_001311034; NP_009181
	NP_776141; NP_001344112
	Wikidata
View/Edit Human	View/Edit Mouse

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.⁵ KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.⁶

Interactions

KLF8 has been shown to interact with CTBP2.⁷

References

GRCh38: Ensembl release 89: ENSG00000102349 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041649 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: KLF8 Kruppel-like factor 8".
Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Archived from the original on 15 December 2018. Retrieved 12 January 2019.
van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.

External links

KLF8 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102349 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041649 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: KLF8 Kruppel-like factor 8".

[molecular_and_cell_biology-6] Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Archived from the original on 15 December 2018. Retrieved 12 January 2019.

[pmid10756197-7] van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.

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Interactions

References

Further reading

External links