KIFC1

KIFC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2REP
Identifiers
Aliases	KIFC1, HSET, KNSL2, kinesin family member C1
External IDs	OMIM: 603763; MGI: 2137414; HomoloGene: 83229; GeneCards: KIFC1; OMA:KIFC1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,409,896 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,151,557 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gonad; ; bone marrow; ; mucosa of transverse colon; ; lymph node; ; appendix; ; stromal cell of endometrium; ; bone marrow cell; ; right testis;
	Top expressed in
	bone marrow; ; yolk sac; ; epiblast; ; urethra; ; ventricular zone; ; thymus; ; hair; ; granulocyte; ; placenta; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; microtubule binding; ATPase activity; ATP binding; microtubule motor activity; minus-end-directed microtubule motor activity;
Cellular component	cytoplasm; endosome; membrane; kinesin complex; spindle; microtubule organizing center; early endosome; microtubule; cytoskeleton; nucleus; mitotic spindle;
Biological process	cell division; mitotic spindle assembly; spermatogenesis; mitotic sister chromatid segregation; cell cycle; mitotic metaphase plate congression; microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	3833
	16580
	ENSG00000233450; ENSG00000204197; ENSG00000237649; ENSG00000056678
	ENSMUSG00000024301
	Q9BW19
	Q9QWT9
	NM_002263
	NM_016761; NM_053173
	NP_002254
	NP_001182227
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.⁵⁶

Function

The protein KifC1 is a member of the kinesin-14 family. KifC1 consists of a C-terminal motor domain, superhelical stalk, and N-terminal tail domain. Tail and motor domains contain microtubule-binding sites. This kinesin moves toward the minus-end of the microtubule and has the ability to slide or crosslink microtubules. KifC1 functions during mitotic spindle formation.

References

ENSG00000204197, ENSG00000237649, ENSG00000056678 GRCh38: Ensembl release 89: ENSG00000233450, ENSG00000204197, ENSG00000237649, ENSG00000056678 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024301 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ando A, Kikuti YY, Kawata H, Okamoto N, Imai T, Eki T, Yokoyama K, Soeda E, Ikemura T, Abe K (Feb 1994). "Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region". Immunogenetics. 39 (3): 194–200. doi:10.1007/bf00241260. PMID 8276466. S2CID 8880453.
"Entrez Gene: KIFC1 kinesin family member C1".

External links

Overview of all the structural information available in the PDB for UniProt: Q9BW19 (Human Kinesin-like protein KIFC1) at the PDBe-KB.

[refGRCh38Ensembl-1] ENSG00000204197, ENSG00000237649, ENSG00000056678 GRCh38: Ensembl release 89: ENSG00000233450, ENSG00000204197, ENSG00000237649, ENSG00000056678 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024301 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8276466-5] Ando A, Kikuti YY, Kawata H, Okamoto N, Imai T, Eki T, Yokoyama K, Soeda E, Ikemura T, Abe K (Feb 1994). "Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region". Immunogenetics. 39 (3): 194–200. doi:10.1007/bf00241260. PMID 8276466. S2CID 8880453.

[entrez-6] "Entrez Gene: KIFC1 kinesin family member C1".

1

2

3

4

5

6

Function

References

Further reading

External links