KIF5B

KIF5B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BG2, 1MKJ, 2P4N, 3J8X, 3J8Y, 4HNA, 4LNU
Identifiers
Aliases	KIF5B, HEL-S-61, KINH, KNS, KNS1, UKHC, kinesin family member 5B
External IDs	OMIM: 602809; MGI: 1098268; HomoloGene: 55829; GeneCards: KIF5B; OMA:KIF5B - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	32,056,425 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	6,242,174 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; caput epididymis; ; optic nerve; ; corpus epididymis; ; mucosa of paranasal sinus; ; inferior ganglion of vagus nerve; ; visceral pleura; ; lower lobe of lung; ; internal globus pallidus; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	globus pallidus; ; lateral geniculate nucleus; ; atrioventricular valve; ; ventral tegmental area; ; pontine nuclei; ; epithelium of lens; ; lateral hypothalamus; ; deep cerebellar nuclei; ; seminal vesicula; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; microtubule binding; protein binding; plus-end-directed microtubule motor activity; ATP binding; JUN kinase binding; cadherin binding; microtubule lateral binding; identical protein binding; ATPase activity;
Cellular component	vesicle; membrane; kinesin complex; endocytic vesicle; microtubule organizing center; membrane-bounded organelle; ciliary rootlet; perinuclear region of cytoplasm; neuron projection; microtubule; cytoskeleton; axonal growth cone; cytoplasm; cytosol; microtubule cytoskeleton; phagocytic vesicle; axon cytoplasm;
Biological process	cytoskeleton-dependent intracellular transport; plus-end-directed vesicle transport along microtubule; cytoplasm organization; vesicle transport along microtubule; positive regulation of potassium ion transport; regulation of membrane potential; positive regulation of synaptic transmission, GABAergic; axon guidance; microtubule-based movement; stress granule disassembly; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of intracellular protein transport; positive regulation of voltage-gated sodium channel activity; positive regulation of vesicle fusion; centrosome localization; brain development; hippocampus development; positive regulation of protein localization to plasma membrane; cellular response to interferon-gamma; anterograde axonal protein transport; anterograde neuronal dense core vesicle transport; retrograde neuronal dense core vesicle transport;
	Sources:Amigo / QuickGO
Orthologs
	3799
	16573
	ENSG00000170759
	ENSMUSG00000006740
	P33176
	Q61768
	NM_004521
	NM_008448
	NP_004512
	NP_032474
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin family member 5B (KIF5B) is a protein that in humans is encoded by the KIF5B gene.⁵⁶ It is part of the kinesin family of motor proteins.

Interactions

KIF5B has been shown to interact with:

KLC1,⁷⁸⁹
KLC2,⁸⁹
SNAP-25,⁷
SNAP23,⁷ and
YWHAH.¹⁰

References

GRCh38: Ensembl release 89: ENSG00000170759 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000006740 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD (Jun 1992). "Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells". The Journal of Cell Biology. 117 (6): 1263–75. doi:10.1083/jcb.117.6.1263. PMC 2289507. PMID 1607388.
"Entrez Gene: KIF5B kinesin family member 5B".
Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. 41 (50): 14906–15. doi:10.1021/bi026417u. PMID 12475239.
Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry. 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. PMID 9624122.
Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. PMC 2156125. PMID 10491391.
Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi:10.1021/bi015946f. PMID 11969417.

External links

Overview of all the structural information available in the PDB for UniProt: P33176 (Kinesin-1 heavy chain) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170759 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006740 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1607388-5] Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD (Jun 1992). "Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells". The Journal of Cell Biology. 117 (6): 1263–75. doi:10.1083/jcb.117.6.1263. PMC 2289507. PMID 1607388.

[entrez-6] "Entrez Gene: KIF5B kinesin family member 5B".

[pmid12475239-7] Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. 41 (50): 14906–15. doi:10.1021/bi026417u. PMID 12475239.

[pmid9624122-8] Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry. 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. PMID 9624122.

[pmid10491391-9] Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. PMC 2156125. PMID 10491391.

[pmid11969417-10] Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. doi:10.1021/bi015946f. PMID 11969417.

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Interactions

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Further reading

External links