Integrin alpha 8

ITGA8
Identifiers
Aliases	ITGA8, integrin subunit alpha 8
External IDs	OMIM: 604063; MGI: 109442; HomoloGene: 37396; GeneCards: ITGA8; OMA:ITGA8 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	15,719,922 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	12,306,733 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; urethra; ; right coronary artery; ; saphenous vein; ; gastric mucosa; ; popliteal artery; ; tibial arteries; ; left coronary artery; ; vena cava;
	Top expressed in
	ascending aorta; ; aortic valve; ; carotid body; ; right lung lobe; ; vas deferens; ; tunica media of zone of aorta; ; left lung lobe; ; vestibular membrane of cochlear duct; ; efferent ductule; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding;
Cellular component	integral component of membrane; perikaryon; membrane; postsynaptic density; focal adhesion; integrin alpha8-beta1 complex; plasma membrane; apical part of cell; cell surface; integrin complex; endoplasmic reticulum; dendritic spine membrane;
Biological process	positive regulation of transforming growth factor beta receptor signaling pathway; cell differentiation; kidney development; establishment of protein localization; extracellular matrix organization; memory; nervous system development; multicellular organism development; brain development; cell adhesion; cell projection organization; inner ear morphogenesis; positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; smooth muscle tissue development; mesodermal cell differentiation; integrin-mediated signaling pathway; substrate adhesion-dependent cell spreading; cell-matrix adhesion; metanephros development; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	8516
	241226
	ENSG00000077943
	ENSMUSG00000026768
	P53708
	A2ARA8
	NM_001291494; NM_003638
	NM_001001309
	NP_001278423; NP_003629
	NP_001001309; NP_001395029; NP_001395030; NP_001395031
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026768 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci. 108 (2): 537–44. doi:10.1242/jcs.108.2.537. PMID 7768999.
"Entrez Gene: ITGA8 integrin, alpha 8".

Further reading

Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin". J. Biol. Chem. 270 (39): 23196–202. doi:10.1074/jbc.270.39.23196. PMID 7559467.
Denda S, Müller U, Crossin KL, et al. (1998). "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C". Biochemistry. 37 (16): 5464–74. doi:10.1021/bi9727489. PMC 2710129. PMID 9548928.
Hartner A, Schöcklmann H, Pröls F, et al. (1999). "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis". Kidney Int. 56 (4): 1468–80. doi:10.1046/j.1523-1755.1999.00662.x. PMID 10504498.
Littlewood Evans A, Müller U (2000). "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1". Nat. Genet. 24 (4): 424–8. doi:10.1038/74286. PMID 10742111. S2CID 2316181.
Brandenberger R, Schmidt A, Linton J, et al. (2001). "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney". J. Cell Biol. 154 (2): 447–58. doi:10.1083/jcb.200103069. PMC 2150762. PMID 11470831.
Ljubimov AV, Saghizadeh M, Pytela R, et al. (2001). "Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas". J. Histochem. Cytochem. 49 (11): 1341–50. doi:10.1177/002215540104901102. PMID 11668187.
Valerius MT, Patterson LT, Feng Y, Potter SS (2002). "Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8090–5. Bibcode:2002PNAS...99.8090V. doi:10.1073/pnas.122229199. PMC 123025. PMID 12060755.
Lu M, Munger JS, Steadele M, et al. (2003). "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1". J. Cell Sci. 115 (Pt 23): 4641–8. doi:10.1242/jcs.00145. PMID 12415008.
Bieritz B, Spessotto P, Colombatti A, et al. (2004). "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation". Kidney Int. 64 (1): 119–27. doi:10.1046/j.1523-1755.2003.00057.x. PMID 12787402.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Ekwa-Ekoka C, Diaz GA, Carlson C, et al. (2005). "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8)". Matrix Biol. 23 (7): 487–96. doi:10.1016/j.matbio.2004.08.005. PMID 15579315.
Scherberich A, Tucker RP, Degen M, et al. (2005). "Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro". Oncogene. 24 (9): 1525–32. doi:10.1038/sj.onc.1208342. PMID 15592496.

External links

ITGA8 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026768 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7768999-5] Schnapp LM, Breuss JM, Ramos DM, Sheppard D, Pytela R (Jul 1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells". J Cell Sci. 108 (2): 537–44. doi:10.1242/jcs.108.2.537. PMID 7768999.

[entrez-6] "Entrez Gene: ITGA8 integrin, alpha 8".

1

2

3

4

5

6