IPO4

IPO4
Identifiers
Aliases	IPO4, Imp4, importin 4
External IDs	MGI: 1923001; HomoloGene: 5835; GeneCards: IPO4; OMA:IPO4 - orthologs
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,873,414 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; gastrocnemius muscle; ; right uterine tube; ; right adrenal gland; ; sural nerve; ; anterior pituitary; ; left adrenal gland; ; kidney; ; skeletal muscle tissue; ; bone marrow cell;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; seminiferous tubule; ; fossa; ; Gonadal ridge; ; condyle; ; vas deferens; ; morula; ; arcuate nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nuclear localization sequence binding;
Cellular component	cytoplasm; nuclear membrane; nuclear pore; membrane; nuclear periphery; nucleus; protein-containing complex;
Biological process	protein transport; DNA replication-dependent chromatin assembly; intracellular protein transport; ribosomal protein import into nucleus; NLS-bearing protein import into nucleus; transport; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	79711
	75751
	n/a
	ENSMUSG00000002319
	Q8TEX9
	Q8VI75
	NM_024658
	NM_024267; NM_001360078
	NP_078934
	NP_077229; NP_001347007
	Wikidata
View/Edit Human	View/Edit Mouse

Importin-4 is a protein that in humans is encoded by the IPO4 gene.⁴⁵

References

GRCm38: Ensembl release 89: ENSMUSG00000002319 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jakel S, Mingot JM, Schwarzmaier P, Hartmann E, Gorlich D (Feb 2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.
"Entrez Gene: IPO4 importin 4".

Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Miyauchi Y, Michigami T, Sakaguchi N, et al. (2006). "Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor". J. Biol. Chem. 280 (49): 40901–8. doi:10.1074/jbc.M509347200. PMID 16207705.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lischka P, Sorg G, Kann M, et al. (2003). "A Nonconventional Nuclear Localization Signal within the UL84 Protein of Human Cytomegalovirus Mediates Nuclear Import via the Importin α/β Pathway". J. Virol. 77 (6): 3734–48. doi:10.1128/JVI.77.6.3734-3748.2003. PMC 149505. PMID 12610148.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000002319 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11823430-4] Jakel S, Mingot JM, Schwarzmaier P, Hartmann E, Gorlich D (Feb 2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.

[entrez-5] "Entrez Gene: IPO4 importin 4".

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