Article · Wikipedia archive · Last revised Jul 9, 2026

Iodophenpropit

Iodophenpropit is a histamine antagonist which binds selectively to the H3 subtype. Its 125I radiolabelled form has been used for mapping the distribution of H3 receptors in animal studies.

Last revised
Jul 9, 2026
Read time
≈ 1 min
Length
192 w
Citations
2
Source
Wikipedia ↗
Iodophenpropit
source ↗
Names
IUPAC name
3-(1H-imidazol-5-yl)propyl N'-[2-(4-iodophenyl)ethyl]imidothiocarbamate
Other names
1-[3-(3H-imidazol-4-yl)propylthio]-N'-[2-(4-iodophenyl)ethyl]formamidine
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
MeSH Iodophenpropit
UNII
  • InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20)
    Key: UBHYDQAARZKHEZ-UHFFFAOYSA-N
  • C1=CC(=CC=C1CCN=C(N)SCCCC2=CN=CN2)I
Properties
C15H19IN4S
Molar mass 414.30763 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Iodophenpropit is a histamine antagonist which binds selectively to the H3 subtype. Its 125I radiolabelled form has been used for mapping the distribution of H3 receptors in animal studies.12

References

References

  1. Jansen, FP; Wu, TS; Voss, HP; Steinbusch, HW; Vollinga, RC; Rademaker, B; Bast, A; Timmerman, H (1994). "Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain". British Journal of Pharmacology. 113 (2): 355–62. doi:10.1111/j.1476-5381.1994.tb16995.x. PMC 1510107. PMID 7834183.
  2. Jansen, FP; Mochizuki, T; Maeyama, K; Leurs, R; Timmerman, H (2000). "Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit". Naunyn-Schmiedeberg's Archives of Pharmacology. 362 (1): 60–7. doi:10.1007/s002100000227. PMID 10935534. S2CID 21293180.