IL22RA1

IL22RA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DGC, 3DLQ
Identifiers
Aliases	IL22RA1, CRF2-9, IL22R, IL22R1, interleukin 22 receptor subunit alpha 1
External IDs	OMIM: 605457; MGI: 2663588; HomoloGene: 10943; GeneCards: IL22RA1; OMA:IL22RA1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	24,143,140 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,479,451 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; jejunal mucosa; ; skin of leg; ; skin of abdomen; ; skin of arm; ; pancreatic ductal cell; ; mucosa of ileum; ; duodenum; ; mucosa of colon; ; gingival epithelium;
	Top expressed in
	jejunum; ; ileum; ; colon; ; duodenum; ; lip; ; zone of skin; ; yolk sac; ; esophagus; ; liver; ; human kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	interferon receptor activity; protein binding; interleukin-20 binding; cytokine receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	defense response to Gram-negative bacterium; biological process; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	58985
	230828
	ENSG00000142677
	ENSMUSG00000037157
	Q8N6P7
	Q80XZ4
	NM_021258
	NM_178257
	NP_067081
	NP_839988
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene.⁵

Function

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.

References

GRCh38: Ensembl release 89: ENSG00000142677 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037157 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Interleukin 22 receptor, alpha 1".

Further reading

Bleicher L, de Moura PR, Watanabe L, Colau D, Dumoutier L, Renauld JC, Polikarpov I (September 2008). "Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism". FEBS Letters. 582 (20): 2985–92. doi:10.1016/j.febslet.2008.07.046. PMID 18675809. S2CID 20952148.
Jones BC, Logsdon NJ, Walter MR (September 2008). "Structure of IL-22 bound to its high-affinity IL-22R1 chain". Structure. 16 (9): 1333–44. doi:10.1016/j.str.2008.06.005. PMC 2637415. PMID 18599299.
de Moura PR, Watanabe L, Bleicher L, Colau D, Dumoutier L, Lemaire MM, Renauld JC, Polikarpov I (April 2009). "Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22". FEBS Letters. 583 (7): 1072–7. doi:10.1016/j.febslet.2009.03.006. PMID 19285080.
Dumoutier L, de Meester C, Tavernier J, Renauld JC (September 2009). "New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain". The Journal of Biological Chemistry. 284 (39): 26377–84. doi:10.1074/jbc.M109.007955. PMC 2785325. PMID 19632985.
Wu PW, Li J, Kodangattil SR, Luxenberg DP, Bennett F, Martino M, Collins M, Dunussi-Joannopoulos K, Gill DS, Wolfman NM, Fouser LA (October 2008). "IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22". Journal of Molecular Biology. 382 (5): 1168–83. doi:10.1016/j.jmb.2008.07.046. PMID 18675824.
Meng S, Gui Q, Xu Q, Lu K, Jiao X, Fan J, Ge B, Ke Y, Zhang S, Wu J, Wang C (August 2010). "Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation". Journal of Molecular Cell Biology. 2 (4): 223–30. doi:10.1093/jmcb/mjq017. PMC 2948820. PMID 20671117.
Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, Pestka S (January 2001). "Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes". The Journal of Biological Chemistry. 276 (4): 2725–32. doi:10.1074/jbc.M007837200. PMID 11035029.
Chang Y, Al-Alwan L, Risse PA, Halayko AJ, Martin JG, Baglole CJ, Eidelman DH, Hamid Q (December 2012). "Th17-associated cytokines promote human airway smooth muscle cell proliferation". FASEB Journal. 26 (12): 5152–60. doi:10.1096/fj.12-208033. PMID 22898922. S2CID 205369384.
Shioya M, Andoh A, Kakinoki S, Nishida A, Fujiyama Y (March 2008). "Interleukin 22 receptor 1 expression in pancreas islets". Pancreas. 36 (2): 197–9. doi:10.1097/MPA.0b013e3181594258. PMID 18376313. S2CID 26713011.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142677 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037157 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Interleukin 22 receptor, alpha 1".

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