IGFBP2

IGFBP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H7T
Identifiers
Aliases	IGFBP2, IBP2, IGF-BP53, insulin like growth factor binding protein 2
External IDs	OMIM: 146731; MGI: 96437; HomoloGene: 499; GeneCards: IGFBP2; OMA:IGFBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	216,664,436 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	72,891,633 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; decidua; ; right coronary artery; ; body of stomach; ; ventricular zone; ; ganglionic eminence; ; olfactory zone of nasal mucosa; ; epithelium of bronchus; ; bronchial epithelial cell;
	Top expressed in
	choroid plexus of fourth ventricle; ; calvaria; ; vestibular sensory epithelium; ; Epithelium of choroid plexus; ; corneal stroma; ; efferent ductule; ; optic nerve; ; transitional epithelium of urinary bladder; ; left lobe of liver; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	insulin-like growth factor binding; growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding; signaling receptor binding;
Cellular component	extracellular region; apical plasma membrane; extracellular exosome; cytoplasmic vesicle; extracellular space;
Biological process	response to estradiol; response to retinoic acid; response to nutrient; female pregnancy; response to steroid hormone; response to mechanical stimulus; ageing; response to glucocorticoid; response to lithium ion; response to estrogen; regulation of insulin-like growth factor receptor signaling pathway; cellular response to hormone stimulus; regulation of cell growth; regulation of growth; negative regulation of canonical Wnt signaling pathway; signal transduction; positive regulation of activated T cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3485
	16008
	ENSG00000115457
	ENSMUSG00000039323
	P18065
	P47877
	NM_001313990; NM_001313992; NM_001313993; NM_000597
	NM_008342; NM_001310659
	NP_000588; NP_001300919; NP_001300921; NP_001300922
	NP_001297588; NP_032368
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene.⁵

References

GRCh38: Ensembl release 89: ENSG00000115457 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000039323 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Zapf J, Kiefer M, Merryweather J, Musiarz F, Bauer D, Born W, Fischer JA, Froesch ER (Oct 1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J Biol Chem. 265 (25): 14892–8. doi:10.1016/S0021-9258(18)77200-1. PMID 1697583.

Further reading

Rajaram S, Baylink DJ, Mohan S (1997). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions". Endocr. Rev. 18 (6): 801–31. doi:10.1210/edrv.18.6.0321. PMID 9408744.
Wolf E, Lahm H, Wu M, et al. (2000). "Effects of IGFBP-2 overexpression in vitro and in vivo". Pediatr. Nephrol. 14 (7): 572–8. doi:10.1007/s004670000362. PMID 10912521. S2CID 5823615.
Chesik D, De Keyser J, Wilczak N (2007). "Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis". Cytokine Growth Factor Rev. 18 (3–4): 267–78. doi:10.1016/j.cytogfr.2007.04.001. PMID 17485236.
Binkert C, Margot JB, Landwehr J, et al. (1992). "Structure of the human insulin-like growth factor binding protein-2 gene". Mol. Endocrinol. 6 (5): 826–36. doi:10.1210/mend.6.5.1376411. PMID 1376411. S2CID 20288398.
Zhou J, Bondy C (1992). "Insulin-like growth factor-II and its binding proteins in placental development". Endocrinology. 131 (3): 1230–40. doi:10.1210/endo.131.3.1380437. PMID 1380437.
Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. doi:10.1016/0006-291X(91)90420-C. PMID 1710112.
Agarwal N, Hsieh CL, Sills D, et al. (1991). "Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)". Exp. Eye Res. 52 (5): 549–61. doi:10.1016/0014-4835(91)90056-K. PMID 1712312.
Roghani M, Lassarre C, Zapf J, et al. (1991). "Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins". J. Clin. Endocrinol. Metab. 73 (3): 658–66. doi:10.1210/jcem-73-3-658. PMID 1714916.
Clemmons DR, Snyder DK, Busby WH (1991). "Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects". J. Clin. Endocrinol. Metab. 73 (4): 727–33. doi:10.1210/jcem-73-4-727. PMID 1716260.
Roghani M, Segovia B, Whitechurch O, Binoux M (1993). "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species". Growth Regul. 1 (3): 125–30. PMID 1726837.
Rosenfeld RG, Pham H, Conover CA, et al. (1989). "Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal and amniotic fluids". J. Clin. Endocrinol. Metab. 68 (3): 638–46. doi:10.1210/jcem-68-3-638. PMID 2465304.
Binkert C, Landwehr J, Mary JL, et al. (1989). "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)". EMBO J. 8 (9): 2497–502. doi:10.1002/j.1460-2075.1989.tb08386.x. PMC 401241. PMID 2479552.
Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. S2CID 22503525.
Zhou J, Bondy C (1993). "Anatomy of the human ovarian insulin-like growth factor system". Biol. Reprod. 48 (3): 467–82. doi:10.1095/biolreprod48.3.467. PMID 7680905.
Han VK, Bassett N, Walton J, Challis JR (1996). "The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface". J. Clin. Endocrinol. Metab. 81 (7): 2680–93. doi:10.1210/jcem.81.7.8675597. PMID 8675597. S2CID 33861826.
Bach LA, Rechler MM (1996). "Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography". Biochim. Biophys. Acta. 1313 (1): 79–88. doi:10.1016/0167-4889(96)00053-5. PMID 8781553.
Ho PJ, Baxter RC (1997). "Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia". Clin. Endocrinol. 46 (3): 333–42. doi:10.1046/j.1365-2265.1997.1100922.x. PMID 9156044. S2CID 23145708.
Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins". Biochim. Biophys. Acta. 1432 (2): 293–301. doi:10.1016/S0167-4838(99)00106-5. PMID 10407151.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115457 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039323 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1697583-5] Zapf J, Kiefer M, Merryweather J, Musiarz F, Bauer D, Born W, Fischer JA, Froesch ER (Oct 1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J Biol Chem. 265 (25): 14892–8. doi:10.1016/S0021-9258(18)77200-1. PMID 1697583.

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