HES3

HES3
Identifiers
Aliases	HES3, bHLHb43, hes family bHLH transcription factor 3
External IDs	OMIM: 609971; MGI: 104877; HomoloGene: 7358; GeneCards: HES3; OMA:HES3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,245,578 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,376,119 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa;
	Top expressed in
	urethra; ; male urethra; ; female urethra; ; cerebellar cortex; ; embryo; ; hair; ; tail of embryo; ; Purkinje cell; ; adrenal medulla; ; pars intermedia;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; transcription factor binding; protein dimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription corepressor activity; sequence-specific DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	nucleus;
Biological process	hindbrain morphogenesis; trochlear nerve development; midbrain-hindbrain boundary morphogenesis; negative regulation of transcription, DNA-templated; in utero embryonic development; negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of timing of neuron differentiation; regulation of neurogenesis; oculomotor nerve development; transcription, DNA-templated; midbrain development; positive regulation of transcription by RNA polymerase II; neural tube development; somitogenesis; Notch signaling pathway; cell differentiation; anterior/posterior pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	390992
	15207
	ENSG00000173673
	ENSMUSG00000028946
	Q5TGS1
	Q61657
	NM_001024598
	NM_008237
	NP_001019769
	NP_032263; NP_001390720; NP_001390721; NP_001390722; NP_001390723
	Wikidata
View/Edit Human	View/Edit Mouse

Hes family bHLH transcription factor 3 is a protein that in humans is encoded by the HES3 gene.⁵

References

GRCh38: Ensembl release 89: ENSG00000173673 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028946 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Hes family bHLH transcription factor 3".

Further reading

Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
Katoh M, Katoh M (August 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.
Fukami M, Wada Y, Okada M, Kato F, Katsumata N, Baba T, Morohashi K, Laporte J, Kitagawa M, Ogata T (February 2008). "Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence". The Journal of Biological Chemistry. 283 (9): 5525–32. doi:10.1074/jbc.M703289200. PMID 18162467.
Park DM, Jung J, Masjkur J, Makrogkikas S, Ebermann D, Saha S, Rogliano R, Paolillo N, Pacioni S, McKay RD, Poser S, Androutsellis-Theotokis A (2013). "Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics". Scientific Reports. 3: 1095. Bibcode:2013NatSR...3E1095P. doi:10.1038/srep01095. PMC 3566603. PMID 23393614.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173673 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028946 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Hes family bHLH transcription factor 3".

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