Article · Wikipedia archive · Last revised Jul 10, 2026

HDLBP

Vigilin is a 110 kDa protein that in humans is encoded by the HDLBP gene.

Last revised

Jul 10, 2026

Read time

≈ 4 min

Length

860 w

Citations

11

Source

HDLBP

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1VIG, 1VIH, 2CTE, 2CTF, 2CTJ, 2CTK, 2CTL, 2CTM

Identifiers

HDLBP, HBP, PRO2900, VGL, high density lipoprotein binding protein

External IDs

OMIM: 142695; MGI: 99256; HomoloGene: 38035; GeneCards: HDLBP; OMA:HDLBP - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)¹

Band	2q37.3	Start	241,227,264 bp¹
Band	2q37.3	End	241,317,061 bp¹

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)²

Band	1 D\|1 47.24 cM	Start	93,333,662 bp²
Band	1 D\|1 47.24 cM	End	93,406,537 bp²

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

body of pancreas

Achilles tendon

anterior pituitary

left testis

epithelium of colon

right testis

right lobe of thyroid gland

muscle of thigh

body of stomach

Top expressed in

tail of embryo

lacrimal gland

genital tubercle

calvaria

salivary gland

parotid gland

molar

muscle of thigh

gastrula

ankle

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding lipid binding nucleic acid binding RNA binding cadherin binding
Cellular component	plasma membrane nucleus high-density lipoprotein particle cytoplasm cytosol
Biological process	lipid metabolism steroid metabolic process lipid transport cholesterol metabolic process high-density lipoprotein particle clearance transport
Sources:Amigo / QuickGO

Species

Human

Mouse


3069


110611


ENSG00000115677


ENSMUSG00000034088


Q00341


Q8VDJ3

RefSeq (mRNA)

NM_001243900 NM_005336 NM_203346 NM_001320965 NM_001320966
NM_001320967


NM_001301364 NM_133808 NM_001357556

RefSeq (protein)

NP_001230829 NP_001307894 NP_001307895 NP_001307896 NP_005327
NP_976221


NP_001288293 NP_598569 NP_001344485

Location (UCSC)

Chr 2: 241.23 – 241.32 Mb

Chr 1: 93.33 – 93.41 Mb

PubMed search

³

⁴

View/Edit Human

View/Edit Mouse

Vigilin is a 110 kDa protein that in humans is encoded by the HDLBP gene.⁵⁶⁷

References

References

GRCh38: Ensembl release 89: ENSG00000115677 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034088 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
McKnight GL, Reasoner J, Gilbert T, Sundquist KO, Hokland B, McKernan PA, Champagne J, Johnson CJ, Bailey MC, Holly R, et al. (Jul 1992). "Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells". J Biol Chem. 267 (17): 12131–41. doi:10.1016/S0021-9258(19)49815-3. PMID 1318310.
Xia YR, Klisak I, Sparkes RS, Oram J, Lusis AJ (Jul 1993). "Localization of the gene for high-density lipoprotein binding protein (HDLBP) to human chromosome 2q37". Genomics. 16 (2): 524–5. doi:10.1006/geno.1993.1221. PMID 8390966.
"Entrez Gene: HDLBP high density lipoprotein binding protein (vigilin)".

Further reading

Further reading

Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects". Mol. Cell. Proteomics. 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
Graham DL, Oram JF (1987). "Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting". J. Biol. Chem. 262 (16): 7439–42. doi:10.1016/S0021-9258(18)47584-9. PMID 3034894.
Plenz G, Kügler S, Schnittger S, et al. (1994). "The human vigilin gene: identification, chromosomal localization and expression pattern". Hum. Genet. 93 (5): 575–82. doi:10.1007/BF00202827. PMID 8168838. S2CID 25536273.
Neu-Yilik G, Zorbas H, Gloe TR, et al. (1993). "Vigilin is a cytoplasmic protein. A study on its expression in primary cells and in established cell lines of different species". Eur. J. Biochem. 213 (2): 727–36. doi:10.1111/j.1432-1033.1993.tb17813.x. PMID 8477745.
Kügler S, Grünweller A, Probst C, et al. (1996). "Vigilin contains a functional nuclear localisation sequence and is present in both the cytoplasm and the nucleus". FEBS Lett. 382 (3): 330–4. doi:10.1016/0014-5793(96)00204-9. PMID 8605996. S2CID 42740112.
Kügler S, Plenz G, Müller PK (1996). "Two additional 5' exons in the human Vigilin gene distinguish it from the chicken gene and provide the structural basis for differential routes of gene expression". Eur. J. Biochem. 238 (2): 410–7. doi:10.1111/j.1432-1033.1996.0410z.x. PMID 8681952.
Chiu DS, Oram JF, LeBoeuf RC, et al. (1998). "High-density lipoprotein-binding protein (HBP)/vigilin is expressed in human atherosclerotic lesions and colocalizes with apolipoprotein E." Arterioscler. Thromb. Vasc. Biol. 17 (11): 2350–8. doi:10.1161/01.ATV.17.11.2350. PMID 9409201.
Kruse C, Willkomm DK, Grünweller A, et al. (2000). "Export and transport of tRNA are coupled to a multi-protein complex". Biochem. J. 346 (Pt 1): 107–15. doi:10.1042/0264-6021:3460107. PMC 1220829. PMID 10657246.
Bocharov AV, Vishnyakova TG, Baranova IN, et al. (2001). "Characterization of a 95 kDa high affinity human high density lipoprotein-binding protein". Biochemistry. 40 (14): 4407–16. doi:10.1021/bi001503k. PMID 11284697.
Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell. Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
Goolsby KM, Shapiro DJ (2003). "RNAi-mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non-dividing human cells but does not initially inhibit protein synthesis". Nucleic Acids Res. 31 (19): 5644–53. doi:10.1093/nar/gkg768. PMC 206468. PMID 14500828.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Vollbrandt T, Willkomm D, Stossberg H, Kruse C (2004). "Vigilin is co-localized with 80S ribosomes and binds to the ribosomal complex through its C-terminal domain". Int. J. Biochem. Cell Biol. 36 (7): 1306–18. doi:10.1016/j.biocel.2003.11.006. PMID 15109574.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.