HIST1H2BI

H2BC10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5KGF
Identifiers
Aliases	H2BC10, H2B/k, H2BFK, histone cluster 1, H2bi, histone cluster 1 H2B family member i, H2B clustered histone 10, HIST1H2BI, H2BC8, H2BC7, H2BC6, H2BC4
External IDs	OMIM: 602807; MGI: 1915274; HomoloGene: 135944; GeneCards: H2BC10; OMA:H2BC10 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	26,273,412 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	23,876,891 bp
RNA expression pattern
	Top expressed in
	bone marrow cell; ; Achilles tendon; ; epithelium of colon; ; thymus; ; jejunal mucosa; ; tonsil; ; oral cavity; ; pylorus; ; cartilage tissue; ; epithelium of bronchus;
	Top expressed in
	blood; ; left colon; ; left lobe of liver; ; seminal vesicula; ; decidua; ; epithelium of stomach; ; Epithelium of choroid plexus; ; intercostal muscle; ; calvaria; ; right lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; protein heterodimerization activity; identical protein binding;
Cellular component	chromosome; nucleosome; extracellular exosome; nucleus; nucleoplasm; extracellular space; cytosol;
Biological process	nucleosome assembly; innate immune response in mucosa; defense response to bacterium; protein ubiquitination; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	8346
	68024
	ENSG00000278588
	ENSMUSG00000018102
	P62807
	Q6ZWY9
	NM_003525
	NM_001290380; NM_023422
	NP_003517; NP_001368918
NP_001171124; NP_001277459; NP_835501; NP_835503; NP_001277309;
	NP_075911
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BI gene.⁵⁶⁷

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.⁷

References

GRCh38: Ensembl release 89: ENSG00000278588 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000018102 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
"Entrez Gene: HIST1H2BI histone cluster 1, H2bi".

Further reading

Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000278588 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018102 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9119399-5] Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.

[pmid12408966-6] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

[entrez-7] "Entrez Gene: HIST1H2BI histone cluster 1, H2bi".

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