GPR78

GPR78
Identifiers
Aliases	GPR78, G protein-coupled receptor 78
External IDs	OMIM: 606921; HomoloGene: 50960; GeneCards: GPR78; OMA:GPR78 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	8,619,761 bp
RNA expression pattern
	Top expressed in
	left ovary; ; right ovary; ; vagina; ; stromal cell of endometrium; ; ectocervix; ; right uterine tube; ; canal of the cervix; ; skin of hip; ; gallbladder; ; prefrontal cortex;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	27201
	n/a
	ENSG00000155269
	n/a
	Q96P69
	n/a
	NM_080819
	n/a
	NP_543009
	n/a
	Wikidata
View/Edit Human

Probable G-protein coupled receptor 78 is a protein that in humans is encoded by the GPR78 gene.³⁴

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]⁴

References

GRCh38: Ensembl release 89: ENSG00000155269 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
"Entrez Gene: GPR78 G protein-coupled receptor 78".

Further reading

van Laar T, Schouten T, Hoogervorst E, Van Eck M, Van Der Eb AJ, Terleth C (2000). "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway". FEBS Lett. 469 (1): 123–31. doi:10.1016/S0014-5793(00)01253-9. PMID 10708769. S2CID 6419566.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Underwood SL, Christoforou A, Thomson PA, Wray NR, Tenesa A, Whittaker J, Adams RA, Le Hellard S, Morris SW (2006). "Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia". Mol. Psychiatry. 11 (4): 384–94. doi:10.1038/sj.mp.4001786. PMID 16389273. S2CID 12678399.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155269 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11574155-3] Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.

[entrez-4] "Entrez Gene: GPR78 G protein-coupled receptor 78".

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