GPR52

GPR52
Identifiers
Aliases	GPR52, G protein-coupled receptor 52
External IDs	OMIM: 604106; MGI: 3643278; HomoloGene: 74561; GeneCards: GPR52; OMA:GPR52 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	174,449,545 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	160,405,544 bp
RNA expression pattern
	Top expressed in
	testicle; ; bone marrow cell; ; nucleus accumbens; ; prefrontal cortex; ; putamen; ; caudate nucleus; ; epithelium of colon; ; Achilles tendon; ; gonad; ; Brodmann area 9;
	Top expressed in
	striatum of neuraxis; ; superior frontal gyrus; ; embryo; ; primary visual cortex; ; hypothalamus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; duodenum; ; granulocyte; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dopamine neurotransmitter receptor activity, coupled via Gs; signal transducer activity; G protein-coupled receptor activity; G protein-coupled photoreceptor activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction; dopamine receptor signaling pathway; locomotory behavior; phototransduction; detection of visible light; cellular response to light stimulus;
	Sources:Amigo / QuickGO
Orthologs
	9293
	620246
	ENSG00000203737
	ENSMUSG00000118401
	Q9Y2T5
	P0C5J4
	NM_005684
	NM_001146330; NM_001368668
	NP_005675
	NP_001139802; NP_001355597
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 52 is a protein that in humans is encoded by the GPR52 gene.⁵⁶

Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM]⁶

Cannabidiol, CBD, and O-1918 are Inverse agonist at GPR52.⁷

References

GRCh38: Ensembl release 89: ENSG00000203737 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000118401 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, et al. (February 1999). "Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain". Brain Research. Molecular Brain Research. 64 (2): 193–198. doi:10.1016/S0169-328X(98)00277-0. PMID 9931487.
"Entrez Gene: GPR52 G protein-coupled receptor 52".
Stott LA, Brighton CA, Brown J, Mould R, Bennett KA, Newman R, et al. (June 2021). "Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918". Heliyon. 7 (6) e07201. Bibcode:2021Heliy...707201S. doi:10.1016/j.heliyon.2021.e07201. PMC 8219759. PMID 34189291.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000203737 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000118401 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9931487-5] Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, et al. (February 1999). "Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain". Brain Research. Molecular Brain Research. 64 (2): 193–198. doi:10.1016/S0169-328X(98)00277-0. PMID 9931487.

[entrez-6] "Entrez Gene: GPR52 G protein-coupled receptor 52".

[7] Stott LA, Brighton CA, Brown J, Mould R, Bennett KA, Newman R, et al. (June 2021). "Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918". Heliyon. 7 (6) e07201. Bibcode:2021Heliy...707201S. doi:10.1016/j.heliyon.2021.e07201. PMC 8219759. PMID 34189291.

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