GPR45

GPR45
Identifiers
Aliases	GPR45, PSP24, PSP24(ALPHA), PSP24A, G protein-coupled receptor 45
External IDs	OMIM: 604838; MGI: 2135882; HomoloGene: 5228; GeneCards: GPR45; OMA:GPR45 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	105,243,467 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	43,074,616 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; hypothalamus; ; nucleus accumbens; ; amygdala; ; embryo; ; caudate nucleus;
	Top expressed in
	lumbar subsegment of spinal cord; ; ventricular zone; ; ganglionic eminence; ; arcuate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; paraventricular nucleus of hypothalamus; ; primary visual cortex; ; dorsomedial hypothalamic nucleus; ; superior frontal gyrus; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	11250
	93690
	ENSG00000135973
	ENSMUSG00000041907
	Q9Y5Y3
	Q9EQQ4
	NM_007227
	NM_053107
	NP_009158
	NP_444337
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.⁵⁶

This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system.⁶

References

GRCh38: Ensembl release 89: ENSG00000135973 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041907 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.
"Entrez Gene: GPR45 G protein-coupled receptor 45".

Further reading

Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.
Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135973 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041907 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10036181-5] Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.

[entrez-6] "Entrez Gene: GPR45 G protein-coupled receptor 45".

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