GNAT3

GNAT3
Identifiers
Aliases	GNAT3, GDCA, G protein subunit alpha transducin 3, HG1E
External IDs	OMIM: 139395; MGI: 3588268; HomoloGene: 24284; GeneCards: GNAT3; OMA:GNAT3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	80,512,064 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	18,224,832 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; tibialis anterior muscle; ; duodenum; ; abdominal wall; ; mucosa of small intestine; ; prefrontal cortex; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; large intestine;
	Top expressed in
	mucosa of large intestine; ; intestinal epithelium; ; tongue; ; epithelium of colon; ; mucosa of small intestine; ; neural layer of retina; ; vallate papilla; ; secondary oocyte; ; epithelium of small intestine; ; white adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; metal ion binding; nucleotide binding; guanyl nucleotide binding; G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity;
Cellular component	acrosomal vesicle; cytoplasm; axoneme; heterotrimeric G-protein complex; apical plasma membrane; plasma membrane; photoreceptor outer segment; photoreceptor inner segment; protein-containing complex;
Biological process	signal transduction; sensory perception of umami taste; response to nicotine; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; sensory perception of bitter taste; sensory perception of taste; sensory perception of sweet taste; protein folding; detection of chemical stimulus involved in sensory perception of bitter taste; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	346562
	242851
	ENSG00000214415
	ENSMUSG00000028777
	A8MTJ3
	Q3V3I2
	NM_001102386
	NM_001081143
	NP_001095856
	NP_001074612
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein subunit that in humans is encoded by the GNAT3 gene.⁵

Gustducin alpha-3 chain is a subunit of the heterotrimeric G protein gustducin that is responsible for basic taste.

References

GRCh38: Ensembl release 89: ENSG00000214415 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028777 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: guanine nucleotide binding protein".

Further reading

Oldham WM, Van Eps N, Preininger AM, et al. (2006). "Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins". Nat. Struct. Mol. Biol. 13 (9): 772–7. doi:10.1038/nsmb1129. PMID 16892066. S2CID 290532.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Rozengurt N, Wu SV, Chen MC, et al. (2006). "Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon". Am. J. Physiol. Gastrointest. Liver Physiol. 291 (5): G792-802. doi:10.1152/ajpgi.00074.2006. PMID 16728727.
Huang L, Shanker YG, Dubauskaite J, et al. (1999). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium". Nat. Neurosci. 2 (12): 1055–62. doi:10.1038/15981. PMID 10570481. S2CID 24494794.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID 18240029. S2CID 45173229.
Margolskee RF, Dyer J, Kokrashvili Z, et al. (2007). "T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15075–80. Bibcode:2007PNAS..10415075M. doi:10.1073/pnas.0706678104. PMC 1986615. PMID 17724332.
Takami S, Getchell TV, McLaughlin SK, et al. (1994). "Human taste cells express the G protein alpha-gustducin and neuron-specific enolase". Brain Res. Mol. Brain Res. 22 (1–4): 193–203. doi:10.1016/0169-328X(94)90047-7. PMID 8015379.
Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. (2007). "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1". Proc. Natl. Acad. Sci. U.S.A. 104 (38): 15069–74. Bibcode:2007PNAS..10415069J. doi:10.1073/pnas.0706890104. PMC 1986614. PMID 17724330.
Li X, Staszewski L, Xu H, et al. (2002). "Human receptors for sweet and umami taste". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692–6. Bibcode:2002PNAS...99.4692L. doi:10.1073/pnas.072090199. PMC 123709. PMID 11917125.
Fehr J, Meyer D, Widmayer P, et al. (2007). "Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa". J. Comp. Physiol. A. 193 (1): 21–34. doi:10.1007/s00359-006-0168-8. PMID 17021831. S2CID 25762931.
Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). "Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein". Nature. 369 (6482): 621–8. Bibcode:1994Natur.369..621L. doi:10.1038/369621a0. PMID 8208289. S2CID 4238569.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000214415 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028777 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: guanine nucleotide binding protein".

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