Gem-associated protein 5

GEMIN5
Identifiers
Aliases	GEMIN5, GEMIN-5, gem nuclear organelle associated protein 5, NEDCAM
External IDs	OMIM: 607005; MGI: 2449311; HomoloGene: 9155; GeneCards: GEMIN5; OMA:GEMIN5 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	154,938,211 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	58,059,365 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; tibialis anterior muscle; ; gonad; ; deltoid muscle; ; ventricular zone; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; gastrocnemius muscle; ; quadriceps femoris muscle;
	Top expressed in
	spermatocyte; ; spermatid; ; epiblast; ; tail of embryo; ; seminiferous tubule; ; internal carotid artery; ; morula; ; morula; ; genital tubercle; ; intestinal villus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	snRNA binding; protein binding; RNA 7-methylguanosine cap binding; mRNA 3'-UTR binding; U1 snRNA binding; U4 snRNA binding; U4atac snRNA binding; ribosome binding; RNA binding;
Cellular component	cytoplasm; SMN complex; SMN-Sm protein complex; cytosol; nuclear body; membrane; gemini of coiled bodies; nucleoplasm; nucleus; cytosolic large ribosomal subunit; SMN-Gemin2 complex;
Biological process	mRNA splicing, via spliceosome; mRNA processing; RNA splicing; spliceosomal snRNP assembly; import into nucleus; protein biosynthesis; regulation of translation; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	25929
	216766
	ENSG00000082516
	ENSMUSG00000037275
	Q8TEQ6
	Q8BX17
	NM_015465; NM_001252156
	NM_001166669; NM_001166670; NM_001166671; NM_172558; NM_001374702
	NP_001239085; NP_056280
	NP_001160141; NP_001160142; NP_001160143; NP_766146; NP_001361631
	Wikidata
View/Edit Human	View/Edit Mouse

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.⁵⁶

Function

Gem-associated protein 5 is part of the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), gem-associated protein 2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).⁶

Interactions

GEMIN5 has been shown to interact with DDX20⁵⁷ and SMN1.⁵

References

GRCh38: Ensembl release 89: ENSG00000082516 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037275 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (Feb 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J Biol Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
"Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5".
Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.

Further reading

Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Battle DJ, Lau CK, Wan L, Deng H, Lotti F, Dreyfuss G (2006). "The Gemin5 protein of the SMN complex identifies snRNAs". Mol. Cell. 23 (2): 273–9. doi:10.1016/j.molcel.2006.05.036. PMID 16857593.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Kim EK, Noh KT, Yoon JH, Cho JH, Yoon KW, Dreyfuss G, Choi EJ (2007). "Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5". Cell Death Differ. 14 (8): 1518–28. doi:10.1038/sj.cdd.4402157. PMID 17541429.
Hao le T, Fuller HR, Lam le T, Le TT, Burghes AH, Morris GE (2007). "Absence of gemin5 from SMN complexes in nuclear Cajal bodies". BMC Cell Biol. 8: 28. doi:10.1186/1471-2121-8-28. PMC 1939999. PMID 17640370.
Battle DJ, Kasim M, Wang J, Dreyfuss G (2007). "SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate". J. Biol. Chem. 282 (38): 27953–9. doi:10.1074/jbc.M702317200. PMID 17640873.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000082516 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037275 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11714716-5] Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (Feb 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J Biol Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.

[entrez-6] "Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5".

[pmid11914277-7] Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.

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