GCC1

GCC1
Identifiers
Aliases	GCC1, GCC1P, GCC88, GRIP and coiled-coil domain containing 1
External IDs	OMIM: 607418; MGI: 1921625; HomoloGene: 11567; GeneCards: GCC1; OMA:GCC1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	127,593,611 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	28,428,389 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; islet of Langerhans; ; granulocyte; ; stromal cell of endometrium; ; blood; ; right testis; ; left testis; ; sperm; ; nipple; ; skin of thigh;
	Top expressed in
	granulocyte; ; supraoptic nucleus; ; ascending aorta; ; spermatocyte; ; islet of Langerhans; ; aortic valve; ; stria vascularis; ; spermatid; ; jejunum; ; transitional epithelium of urinary bladder;
	More reference expression data
	More reference expression data
Orthologs
	79571
	74375
	ENSG00000179562
	ENSMUSG00000029708
	Q96CN9
	Q9D4H2
	NM_024523
	NM_028900
	NP_078799
	NP_083176
	Wikidata
View/Edit Human	View/Edit Mouse

GRIP and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the GCC1 gene.⁵⁶

Function

The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport.⁶

Interactions

GCC1 has been shown to interact with TRIM29.⁷

References

GRCh38: Ensembl release 89: ENSG00000179562 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029708 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA (May 1999). "A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins". Curr. Biol. 9 (7): 385–8. Bibcode:1999CBio....9..385K. doi:10.1016/S0960-9822(99)80168-7. PMID 10209125. S2CID 14342088.
"Entrez Gene: GCC1 GRIP and coiled-coil domain containing 1".
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

Luke MR, Kjer-Nielsen L, Brown DL, Stow JL, Gleeson PA (2003). "GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network". J. Biol. Chem. 278 (6): 4216–26. doi:10.1074/jbc.M210387200. PMID 12446665.
Lu L, Hong W (2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
Luke MR, Houghton F, Perugini MA, Gleeson PA (2005). "The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers". Biochem. J. 388 (Pt 3): 835–41. doi:10.1042/BJ20041810. PMC 1183463. PMID 15654769.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179562 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029708 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10209125-5] Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA (May 1999). "A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins". Curr. Biol. 9 (7): 385–8. Bibcode:1999CBio....9..385K. doi:10.1016/S0960-9822(99)80168-7. PMID 10209125. S2CID 14342088.

[entrez-6] "Entrez Gene: GCC1 GRIP and coiled-coil domain containing 1".

[pmid16189514-7] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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