FMNL3

FMNL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4EAH
Identifiers
Aliases	FMNL3, FHOD3, WBP-3, WBP3, FRL2, formin like 3
External IDs	OMIM: 616288; MGI: 109569; HomoloGene: 69101; GeneCards: FMNL3; OMA:FMNL3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	49,708,165 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,268,363 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; appendix; ; right coronary artery; ; stromal cell of endometrium; ; lymph node; ; Achilles tendon; ; apex of heart; ; granulocyte; ; left coronary artery; ; right lung;
	Top expressed in
	primary oocyte; ; granulocyte; ; calvaria; ; internal carotid artery; ; external carotid artery; ; secondary oocyte; ; zygote; ; endocardial cushion; ; semi-lunar valve; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activating protein binding; actin binding;
Cellular component	cytoplasm; membrane; Golgi apparatus; cytosol; plasma membrane; intracellular membrane-bounded organelle;
Biological process	multicellular organism development; actin cytoskeleton organization; angiogenesis; cellular component organization; cytoskeleton organization; regulation of cell shape; cell migration; cortical actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	91010
	22379
	ENSG00000161791
	ENSMUSG00000023008
	Q8IVF7
	Q6ZPF4
	NM_175736; NM_198900; NM_001367835
	NM_011711; NM_001310622; NM_001310623
	NP_783863; NP_944489; NP_001354764
	NP_001297551; NP_001297552; NP_035841
	Wikidata
View/Edit Human	View/Edit Mouse

Formin-like protein 3 (FMNL3), also known as WW domain-binding protein 3 (WBP-3), is a protein that in humans is encoded by the FMNL3 gene.⁵⁶

Function

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described.⁵ The C-terminus has been shown to accelerate actin polymerization activity of this protein through its WH2-like motif.⁷ FMNL3 has been crystallized in complex with actin providing insight into the mechanism of formin-mediated actin nucleation.⁸

References

GRCh38: Ensembl release 89: ENSG00000161791 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000023008 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: formin-like 3".
Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". International Journal of Oncology. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
Heimsath EG, Higgs HN (Jan 2012). "The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends". The Journal of Biological Chemistry. 287 (5): 3087–98. doi:10.1074/jbc.M111.312207. PMC 3270965. PMID 22094460.
Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ (Jan 2013). "FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation". Nature Structural & Molecular Biology. 20 (1): 111–8. doi:10.1038/nsmb.2462. PMC 3876896. PMID 23222643.

FMNL3

Function

See also

References

Further reading