Article · Wikipedia archive · Last revised Jun 17, 2026

Fluminorex

Fluminorex is a centrally acting sympathomimetic which is related to other drugs such as aminorex and pemoline. It was developed as an appetite suppressant by McNeil Laboratories in the 1950s.

Last revised
Jun 17, 2026
Read time
≈ 1 min
Length
171 w
Citations
4
Source
Wikipedia ↗
Fluminorex
Clinical data
ATC code
  • none
Identifiers
  • (RS)-5-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazol-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H9F3N2O
Molar mass230.190 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • FC(F)(F)c1ccc(cc1)C2O\C(=N/C2)N
  • InChI=1S/C10H9F3N2O/c11-10(12,13)7-3-1-6(2-4-7)8-5-15-9(14)16-8/h1-4,8H,5H2,(H2,14,15) checkY
  • Key:NMGYDYBWRZHLHR-UHFFFAOYSA-N checkY
  (verify)

Fluminorex is a centrally acting sympathomimetic which is related to other drugs such as aminorex and pemoline. It was developed as an appetite suppressant by McNeil Laboratories in the 1950s.12

Synthesis

Synthesis:3 Patent (Ex XV):4 source ↗

2-amino-1-[4-(trifluoromethyl)phenyl]ethanol [776-02-3] (1) cyanogen bromide [506-68-3] (2)

See also

See also

References

References

  1. US Patent 3278382 - 2-amino-5-aryloxazoline compositions and methods of using same
  2. Maier J, Mayer FP, Brandt SD, Sitte HH (October 2018). "DARK Classics in Chemical Neuroscience: Aminorex Analogues". ACS Chemical Neuroscience. 9 (10): 2484–2502. doi:10.1021/acschemneuro.8b00415. PMC 6287711. PMID 30269490.
  3. Poos, G. I., Carson, J. R., Rosenau, J. D., Roszkowski, A. P., Kelley, N. M., McGowin, J. (May 1963). "2-amino-5-Aryl-2-oxazolines. Potent New Anorectic Agents". Journal of Medicinal Chemistry. 6 (3): 266–272. doi:10.1021/jm00339a011. PMID 14185981.
  4. Poos George Ireland, U.S. patent 3,278,382 (1966 to Janssen Pharmaceuticals Inc).