FKBP3

FKBP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PBK, 2KFV, 2MPH, 5D75
Identifiers
Aliases	FKBP3, FKBP-25, FKBP-3, FKBP25, PPIase, FK506 binding protein 3, FKBP prolyl isomerase 3
External IDs	OMIM: 186947; MGI: 1353460; HomoloGene: 1525; GeneCards: FKBP3; OMA:FKBP3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	45,135,319 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	65,120,781 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of biceps brachii; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; Brodmann area 23; ; body of tongue; ; muscle of thigh; ; gastrocnemius muscle; ; sperm; ; thoracic diaphragm; ; right ventricle;
	Top expressed in
	medial vestibular nucleus; ; mammillary body; ; lateral hypothalamus; ; intercostal muscle; ; ventromedial nucleus; ; tail of embryo; ; deep cerebellar nuclei; ; lateral septal nucleus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	isomerase activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; RNA binding; signaling receptor activity;
Cellular component	nucleus; cytoplasm;
Biological process	chaperone-mediated protein folding; protein peptidyl-prolyl isomerization;
	Sources:Amigo / QuickGO
Orthologs
	2287
	30795
	ENSG00000100442
	ENSMUSG00000020949
	Q00688
	Q62446
	NM_002013
	NM_013902
	NP_002004
	NP_038930
	Wikidata
View/Edit Human	View/Edit Mouse

FK506-binding protein 3 also known as FKBP25 is a protein that in humans is encoded by the FKBP3 gene.⁵⁶⁷

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.⁸⁷

Interactions

FKBP3 has been shown to interact with YY1,⁹ HDAC1,⁹ Histone deacetylase 2,⁹ DNA,¹⁰ and Mdm2.¹¹ Both crystal structure of FKBP25 with FK506 and the NMR structure of full length FKBP25 has been published with PDB ID 5D75 and 2MPH respectively.⁸¹⁰

References

GRCh38: Ensembl release 89: ENSG00000100442 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020949 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hung DT, Schreiber SL (June 1992). "cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein". Biochemical and Biophysical Research Communications. 184 (2): 733–738. Bibcode:1992BBRC..184..733H. doi:10.1016/0006-291X(92)90651-Z. PMID 1374240.
Porat R, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA (May 1992). "Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells". FASEB Journal. 6 (7): 2482–2486. doi:10.1096/fasebj.6.7.1532945. PMID 1532945. S2CID 29899093.
"Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa".
Prakash A, Rajan S, Yoon HS (April 2016). "Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506". Protein Science. 25 (4): 905–910. doi:10.1002/pro.2875. PMC 4941220. PMID 26749369.
Yang WM, Yao YL, Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". The EMBO Journal. 20 (17): 4814–4825. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
Prakash A, Shin J, Rajan S, Yoon HS (2016). "Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin". Nucleic Acids Research. 44 (6): 2909–2925. doi:10.1093/nar/gkw001. PMC 4824100. PMID 26762975.
Ochocka AM, Kampanis P, Nicol S, Allende-Vega N, Cox M, Marcar L, et al. (February 2009). "FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53". FEBS Letters. 583 (4): 621–626. Bibcode:2009FEBSL.583..621O. doi:10.1016/j.febslet.2009.01.009. PMID 19166840. S2CID 6110.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Peptidyl-prolyl cis-trans isomerase FKBP3
PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Peptidyl-prolyl cis-trans isomerase FKBP3

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100442 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020949 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1374240-5] Hung DT, Schreiber SL (June 1992). "cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein". Biochemical and Biophysical Research Communications. 184 (2): 733–738. Bibcode:1992BBRC..184..733H. doi:10.1016/0006-291X(92)90651-Z. PMID 1374240.

[pmid1532945-6] Porat R, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA (May 1992). "Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells". FASEB Journal. 6 (7): 2482–2486. doi:10.1096/fasebj.6.7.1532945. PMID 1532945. S2CID 29899093.

[entrez-7] "Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa".

[Prakash_905–910-8] Prakash A, Rajan S, Yoon HS (April 2016). "Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506". Protein Science. 25 (4): 905–910. doi:10.1002/pro.2875. PMC 4941220. PMID 26749369.

[pmid11532945-9] Yang WM, Yao YL, Seto E (September 2001). "The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1". The EMBO Journal. 20 (17): 4814–4825. doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.

[pmid26762975-10] Prakash A, Shin J, Rajan S, Yoon HS (2016). "Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin". Nucleic Acids Research. 44 (6): 2909–2925. doi:10.1093/nar/gkw001. PMC 4824100. PMID 26762975.

[pmid19166840-11] Ochocka AM, Kampanis P, Nicol S, Allende-Vega N, Cox M, Marcar L, et al. (February 2009). "FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53". FEBS Letters. 583 (4): 621–626. Bibcode:2009FEBSL.583..621O. doi:10.1016/j.febslet.2009.01.009. PMID 19166840. S2CID 6110.

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Function

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References

Further reading

External links