FGFBP1

FGFBP1
Identifiers
Aliases	FGFBP1, FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17, fibroblast growth factor binding protein 1
External IDs	OMIM: 607737; MGI: 1096350; HomoloGene: 3766; GeneCards: FGFBP1; OMA:FGFBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	15,938,740 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	44,139,121 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; gums; ; gingival epithelium; ; mucosa of esophagus; ; oral cavity; ; mucosa of transverse colon; ; human penis; ; vulva; ; skin of abdomen; ; skin of leg;
	Top expressed in
	corneal stroma; ; mucous cell of stomach; ; skin of abdomen; ; epithelium of stomach; ; optic nerve; ; esophagus; ; umbilical cord; ; lip; ; pyloric antrum; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor binding; heparin binding; protein binding; growth factor binding;
Cellular component	extracellular region; cell surface; plasma membrane; membrane; extracellular space;
Biological process	positive regulation of fibroblast growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; signal transduction; positive regulation of cell population proliferation; negative regulation of cell population proliferation; cell-cell signaling; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9982
	14181
	ENSG00000137440
	ENSMUSG00000048373
	Q14512
	O70514
	NM_005130
	NM_001271616; NM_008009
	NP_005121
	NP_001258545; NP_032035
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.⁵⁶⁷

FGFBP1, or HBP17, binds to both acidic FGF1 and basic FGF2 fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2).[supplied by OMIM]⁷

Interactions

FGFBP1 has been shown to interaction with Perlecan.⁵

References

GRCh38: Ensembl release 89: ENSG00000137440 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000048373 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263–71. doi:10.1074/jbc.M011493200. PMID 11148217.
Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25): 16778–85. doi:10.1016/S0021-9258(18)55368-0. PMID 1885605.
"Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

Further reading

Abuharbeid S, Czubayko F, Aigner A (2006). "The fibroblast growth factor-binding protein FGF-BP". Int. J. Biochem. Cell Biol. 38 (9): 1463–8. doi:10.1016/j.biocel.2005.10.017. PMID 16324873.
Lange LG, Sytkowski AJ, Vallee BL (1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features". Biochemistry. 15 (21): 4687–93. doi:10.1021/bi00666a023. PMID 9982.
Czubayko F, Liaudet-Coopman ED, Aigner A, et al. (1997). "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer". Nat. Med. 3 (10): 1137–40. doi:10.1038/nm1097-1137. PMID 9334727. S2CID 3633113.
Wang XC, Chen JH, Crab JW, Sato JD (1998). "Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site". Biochem. Mol. Biol. Int. 46 (1): 81–7. doi:10.1080/15216549800203582. PMID 9784842. S2CID 44789730.
Harris VK, Coticchia CM, Kagan BL, et al. (2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways". J. Biol. Chem. 275 (15): 10802–11. doi:10.1074/jbc.275.15.10802. PMID 10753873.
Sauter ER, Nesbit M, Tichansky D, et al. (2001). "Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium". Int. J. Cancer. 92 (3): 374–81. doi:10.1002/ijc.1207. PMID 11291074. S2CID 20415335.
Chen JH, Wang XC, Sato JD (2001). "Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells". Cell Biol. Int. 25 (6): 567–70. doi:10.1006/cbir.2000.0688. PMID 11407864. S2CID 19909718.
Tassi E, Al-Attar A, Aigner A, et al. (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein". J. Biol. Chem. 276 (43): 40247–53. doi:10.1074/jbc.M104933200. PMID 11509569.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beer HD, Bittner M, Niklaus G, et al. (2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair". Oncogene. 24 (34): 5269–77. doi:10.1038/sj.onc.1208560. PMID 15806171. S2CID 75364.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Xie B, Tassi E, Swift MR, et al. (2006). "Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display". J. Biol. Chem. 281 (2): 1137–44. doi:10.1074/jbc.M510754200. PMID 16257968.
Ray PE, Tassi E, Liu XH, Wellstein A (2006). "Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome". Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 (1): R105–13. doi:10.1152/ajpregu.00492.2005. PMID 16352855. S2CID 25248653.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137440 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048373 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11148217-5] Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263–71. doi:10.1074/jbc.M011493200. PMID 11148217.

[pmid1885605-6] Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25): 16778–85. doi:10.1016/S0021-9258(18)55368-0. PMID 1885605.

[entrez-7] "Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

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