Article · Wikipedia archive · Last revised Jul 11, 2026

FG5865

FG5865 is from the diphenylbutylpiperazine class of agents. It is a 5-HT1A agonist and a 5-HT2A antagonist.

Last revised
Jul 11, 2026
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≈ 1 min
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188 w
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Wikipedia ↗
FG5865
Identifiers
  • 2-[4-[4,4-Bis(4-fluorophenyl)butyl]piperazin-1-yl]pyridine-3-carboxamide
PubChem CID
ChemSpider
Chemical and physical data
FormulaC26H28F2N4O
Molar mass450.534 g·mol−1
3D model (JSmol)
  • C1CN(CCN1CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C4=C(C=CC=N4)C(=O)N
  • InChI=1S/C26H28F2N4O/c27-21-9-5-19(6-10-21)23(20-7-11-22(28)12-8-20)4-2-14-31-15-17-32(18-16-31)26-24(25(29)33)3-1-13-30-26/h1,3,5-13,23H,2,4,14-18H2,(H2,29,33)
  • Key:KLMRSRHIWFLPBI-UHFFFAOYSA-N

FG5865 is from the diphenylbutylpiperazine class of agents. It is a 5-HT1A agonist and a 5-HT2A antagonist.1

It is believed to be an anxiolytic agent with treatment in substance abuse disorders particularly alcoholism.23

There is evidence to suggest that FG5865 is a SNDRI.4

See also

See also

References

References

  1. Myers RD (1994). "New drugs for the treatment of experimental alcoholism". review. Alcohol. 11 (6). Fayetteville, N.Y.: 439–451. doi:10.1016/0741-8329(94)90064-7. PMID 7865140.
  2. Hjorth S, Pettersson G (July 1993). "5-HT1A autoreceptor-mediated effects of the amperozide congeners, FG5865 and FG5893, on rat brain 5-hydroxytryptamine neurochemistry in vivo". European Journal of Pharmacology. 238 (2–3): 357–367. doi:10.1016/0014-2999(93)90867-H. PMID 7691622.
  3. Long, T. (January 1996). "Alcohol intake in high alcohol drinking (HAD) rats is suppressed by FG5865, a novel 5-HT1A agonist/5-HT2 antagonist". Pharmacology Biochemistry and Behavior. 53 (1): 33–40. doi:10.1016/0091-3057(95)00195-6. PMID 8848457.
  4. Pettersson E (August 1995). "Studies of four novel diphenylbutylpiperazinepyridyl derivatives on release and inhibition of reuptake of dopamine, serotonin and noradrenaline by rat brain in vitro". European Journal of Pharmacology. 282 (1–3): 131–135. doi:10.1016/0014-2999(95)00300-A. PMID 7498267.