FEZ2

FEZ2
Identifiers
Aliases	FEZ2, HUM3CL, fasciculation and elongation protein zeta 2
External IDs	OMIM: 604826; MGI: 2675856; HomoloGene: 3742; GeneCards: FEZ2; OMA:FEZ2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	36,646,087 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	78,725,581 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; secondary oocyte; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm; ; deltoid muscle; ; parietal pleura; ; muscle of thigh; ; visceral pleura; ; Brodmann area 23;
	Top expressed in
	epithelium of lens; ; sternocleidomastoid muscle; ; muscle of thigh; ; triceps brachii muscle; ; retinal pigment epithelium; ; right ventricle; ; temporal muscle; ; quadriceps femoris muscle; ; digastric muscle; ; gastrocnemius muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; axon;
Biological process	signal transduction; nervous system development; negative regulation of autophagosome assembly; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	9637
	225020
	ENSG00000171055
	ENSMUSG00000056121
	Q9UHY8
	Q6TYB5
	NM_001042548; NM_005102
	NM_001285940; NM_001285946; NM_001285949; NM_199448; NM_001360407
	NP_001036013; NP_005093
	NP_001272869; NP_001272875; NP_001272878; NP_955519; NP_001347336
	Wikidata
View/Edit Human	View/Edit Mouse

Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene.⁵⁶

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.⁶

Interactions

FEZ2 has been shown to interact with Protein kinase Mζ.⁷

References

GRCh38: Ensembl release 89: ENSG00000171055 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000056121 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408.
"Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)".
Fujita, Toshitsugu; Ikuta Junko; Hamada Juri; Okajima Toshihide; Tatematsu Kenji; Tanizawa Katsuyuki; Kuroda Shun'ichi (Jan 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3). United States: 738–44. doi:10.1016/j.bbrc.2003.12.006. ISSN 0006-291X. PMID 14697253.

Further reading

Ranes-Goldberg MG, Hori T, Mohan-Peterson S, Spits H (1993). "Identification of human pre-T/NK cell-associated genes". J. Immunol. 151 (10): 5810–21. doi:10.4049/jimmunol.151.10.5810. PMID 8228263. S2CID 39286195.
Kolle G, Georgas K, Holmes GP, et al. (2000). "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis". Mech. Dev. 90 (2): 181–93. doi:10.1016/S0925-4773(99)00248-8. PMID 10642437. S2CID 6529349.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry. 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
Fujita T, Ikuta J, Hamada J, et al. (2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3): 738–44. doi:10.1016/j.bbrc.2003.12.006. PMID 14697253.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Assmann EM, Alborghetti MR, Camargo ME, Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. 281 (15): 9869–81. doi:10.1074/jbc.M513280200. PMID 16484223.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171055 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056121 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9096408-5] Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A. 94 (7): 3414–9. Bibcode:1997PNAS...94.3414B. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408.

[entrez-6] "Entrez Gene: FEZ2 fasciculation and elongation protein zeta 2 (zygin II)".

[pmid14697253-7] Fujita, Toshitsugu; Ikuta Junko; Hamada Juri; Okajima Toshihide; Tatematsu Kenji; Tanizawa Katsuyuki; Kuroda Shun'ichi (Jan 2004). "Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1". Biochem. Biophys. Res. Commun. 313 (3). United States: 738–44. doi:10.1016/j.bbrc.2003.12.006. ISSN 0006-291X. PMID 14697253.

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