FARP1

FARP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H6Y
Identifiers
Aliases	FARP1, CDEP, FARP1-IT1, PLEKHC2, PPP1R75, FERM, ARH/RhoGEF and pleckstrin domain protein 1
External IDs	OMIM: 602654; MGI: 2446173; HomoloGene: 38098; GeneCards: FARP1; OMA:FARP1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	98,455,176 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	121,521,156 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; stromal cell of endometrium; ; corpus epididymis; ; ganglionic eminence; ; human kidney; ; ventricular zone; ; epithelium of colon; ; right lobe of liver; ; parotid gland; ; thyroid gland;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; mandibular prominence; ; molar; ; maxillary prominence; ; hand; ; Gonadal ridge; ; medullary collecting duct; ; vas deferens; ; pituitary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; cytoskeletal protein binding;
Cellular component	cytosol; cell projection; membrane; filopodium; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; dendritic spine; synapse; cell junction; dendrite; neuron projection; cytoskeleton; cytoplasm;
Biological process	dendrite morphogenesis; negative regulation of phosphatase activity; multicellular organism development; synapse assembly; regulation of Rho protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	10160
	223254
	ENSG00000152767
	ENSMUSG00000025555
	Q9Y4F1
	F8VPU2
	NM_001001715; NM_001286839; NM_005766
	NM_134082
	NP_001001715; NP_001273768; NP_005757
	NP_598843
	Wikidata
View/Edit Human	View/Edit Mouse

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.⁵⁶

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.⁶

References

GRCh38: Ensembl release 89: ENSG00000152767 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025555 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y (Jan 1998). "Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors". Biochem Biophys Res Commun. 241 (2): 369–75. doi:10.1006/bbrc.1997.7826. PMID 9425278.
"Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)".

External links

FARP1 human gene location in the UCSC Genome Browser.
FARP1 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152767 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025555 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9425278-5] Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y (Jan 1998). "Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors". Biochem Biophys Res Commun. 241 (2): 369–75. doi:10.1006/bbrc.1997.7826. PMID 9425278.

[entrez-6] "Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)".

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FARP1

See also

References

Further reading

External links