ETV1

ETV1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AVP, 4BNC
Identifiers
Aliases	ETV1, ER81, ETS variant 1, ETS variant transcription factor 1
External IDs	OMIM: 600541; MGI: 99254; HomoloGene: 3636; GeneCards: ETV1; OMA:ETV1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	13,991,425 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	38,920,483 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; parotid gland; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; visceral pleura; ; lower lobe of lung; ; lateral nuclear group of thalamus; ; paraflocculus of cerebellum; ; right ventricle; ; ventricular zone;
	Top expressed in
	parotid gland; ; lobe of cerebellum; ; cerebellar vermis; ; habenula; ; subiculum; ; submandibular gland; ; lacrimal gland; ; internal pyramidal layer of neocortex; ; olfactory bulb; ; Rostral migratory stream;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	positive regulation of transcription, DNA-templated; peripheral nervous system neuron development; mechanosensory behavior; muscle organ development; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; axon guidance; regulation of transcription by RNA polymerase II; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	2115
	14009
	ENSG00000006468
	ENSMUSG00000004151
	P50549
	P41164
NM_001163147; NM_001163148; NM_001163149; NM_001163150; NM_001163151;
	NM_001163152; NM_004956; NM_001370555; NM_001370556
	NM_001163154; NM_007960; NM_001347379
NP_001156619; NP_001156620; NP_001156621; NP_001156622; NP_001156623;
	NP_001156624; NP_004947; NP_001357484; NP_001357485
	NP_001156626; NP_001334308; NP_031986
	Wikidata
View/Edit Human	View/Edit Mouse

ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000006468 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000004151 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Brown TA, McKnight SL (Dec 1992). "Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins". Genes & Development. 6 (12B): 2502–12. doi:10.1101/gad.6.12b.2502. PMID 1340465.
"Entrez Gene: ETV1 ets variant gene 1".

Further reading

Monté D, Coutte L, Baert JL, Angeli I, Stéhelin D, de Launoit Y (Aug 1995). "Molecular characterization of the ets-related human transcription factor ER81". Oncogene. 11 (4): 771–9. PMID 7651741.
Jeon IS, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN (Mar 1995). "A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1". Oncogene. 10 (6): 1229–34. PMID 7700648.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Carrère S, Verger A, Flourens A, Stehelin D, Duterque-Coquillaud M (Jun 1998). "Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains". Oncogene. 16 (25): 3261–8. doi:10.1038/sj.onc.1201868. PMID 9681824. S2CID 26807714.
Coutte L, Monté D, Imai K, Pouilly L, Dewitte F, Vidaud M, Adamski J, Baert JL, de Launoit Y (Nov 1999). "Characterization of the human and mouse ETV1/ER81 transcription factor genes: role of the two alternatively spliced isoforms in the human". Oncogene. 18 (46): 6278–86. doi:10.1038/sj.onc.1203020. PMID 10597226.
Janknecht R (Nov 2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2". The Journal of Biological Chemistry. 276 (45): 41856–61. doi:10.1074/jbc.M106630200. PMID 11551945.
Wu J, Janknecht R (Nov 2002). "Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A". The Journal of Biological Chemistry. 277 (45): 42669–79. doi:10.1074/jbc.M205501200. PMID 12213813.
Janknecht R (Feb 2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene. 22 (5): 746–55. doi:10.1038/sj.onc.1206185. PMID 12569367. S2CID 30183941.
Goel A, Janknecht R (Sep 2003). "Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu". Molecular and Cellular Biology. 23 (17): 6243–54. doi:10.1128/MCB.23.17.6243-6254.2003. PMC 180970. PMID 12917345.
Dowdy SC, Mariani A, Janknecht R (Nov 2003). "HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81". The Journal of Biological Chemistry. 278 (45): 44377–84. doi:10.1074/jbc.M307202200. PMID 12947087.
Goel A, Janknecht R (Apr 2004). "Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu". The Journal of Biological Chemistry. 279 (15): 14909–16. doi:10.1074/jbc.M400036200. PMID 14747462.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gocke CB, Yu H, Kang J (Feb 2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". The Journal of Biological Chemistry. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.

External links

ETV1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006468 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004151 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1340465-5] Brown TA, McKnight SL (Dec 1992). "Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins". Genes & Development. 6 (12B): 2502–12. doi:10.1101/gad.6.12b.2502. PMID 1340465.

[entrez-6] "Entrez Gene: ETV1 ets variant gene 1".

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