Article · Wikipedia archive · Last revised Jul 1, 2026

ERx

ERx is a putative membrane estrogen receptor (mER) of which little is currently known. It was discovered as a gene transcription signature induced by estradiol that is independent of the ERα/ERβ and GPER and was identified using the membrane-impermeable estradiol conjugate E2-BSA in the absence or presence of the ERα/ERβ antagonist fulvestrant (ICI-182,780) and the GPER antagonist G-15.

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ERx is a putative membrane estrogen receptor (mER) of which little is currently known.12 It was discovered as a gene transcription signature induced by estradiol that is independent of the ERα/ERβ and GPER and was identified using the membrane-impermeable estradiol conjugate E2-BSA in the absence or presence of the ERα/ERβ antagonist fulvestrant (ICI-182,780) and the GPER antagonist G-15.12

See also

See also

References

References

  1. Kampa M, Notas G, Pelekanou V, Troullinaki M, Andrianaki M, Azariadis K, et al. (August 2012). "Early membrane initiated transcriptional effects of estrogens in breast cancer cells: First pharmacological evidence for a novel membrane estrogen receptor element (ERx)". Steroids. 77 (10): 959–967. doi:10.1016/j.steroids.2012.02.011. PMID 22406407. S2CID 21837495.
  2. Soltysik K, Czekaj P (April 2013). "Membrane estrogen receptors - is it an alternative way of estrogen action?". Journal of Physiology and Pharmacology. 64 (2): 129–142. PMID 23756388.