EPH receptor A5

EPHA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2R2P, 4ET7
Identifiers
Aliases	EPHA5, CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4, EPH receptor A5
External IDs	OMIM: 600004; MGI: 99654; HomoloGene: 55824; GeneCards: EPHA5; OMA:EPHA5 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	65,670,495 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	84,565,241 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; sperm; ; prefrontal cortex; ; middle temporal gyrus; ; testicle; ; entorhinal cortex; ; dorsolateral prefrontal cortex; ; primary visual cortex; ; frontal pole;
	Top expressed in
	ganglionic eminence; ; ventral tegmental area; ; ventricular zone; ; Region I of hippocampus proper; ; substantia nigra; ; barrel cortex; ; olfactory bulb; ; piriform cortex; ; amygdala; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; GPI-linked ephrin receptor activity; transmembrane-ephrin receptor activity; kinase activity; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; rough endoplasmic reticulum; cell projection; membrane; plasma membrane; integral component of plasma membrane; axon; soma; dendrite; perinuclear region of cytoplasm; external side of plasma membrane; cytoplasm; neuron projection; receptor complex;
Biological process	regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of actin cytoskeleton organization; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of GTPase activity; neuron development; nervous system development; protein phosphorylation; positive regulation of CREB transcription factor activity; peptidyl-tyrosine phosphorylation; hippocampus development; cAMP-mediated signaling; axon guidance; ephrin receptor signaling pathway; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	2044
	13839
	ENSG00000145242
	ENSMUSG00000029245
	P54756
	Q60629
NM_001281765; NM_001281766; NM_001281767; NM_004439; NM_182472;
	NM_001318761
	NM_007937
NP_001268694; NP_001268695; NP_001268696; NP_001305690; NP_004430;
	NP_872272
NP_031963; NP_001389678; NP_001389679; NP_001389680; NP_001389681;
	NP_001389682; NP_001389683; NP_001389684; NP_001389685; NP_001389686; NP_001389687; NP_001389688; NP_001389689; NP_001389690
	Wikidata
View/Edit Human	View/Edit Mouse

EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene.⁵⁶⁷

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.⁷

References

GRCh38: Ensembl release 89: ENSG00000145242 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029245 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.
Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics. 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.
"Entrez Gene: EPHA5 EPH receptor A5".

Further reading

Zhou R (1997). "Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands". Cell Tissue Res. 290 (2): 251–9. doi:10.1007/s004410050929. PMID 9321686. S2CID 1506266.
Caras IW (1997). "A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1". Cell Tissue Res. 290 (2): 261–4. doi:10.1007/s004410050930. PMID 9321687. S2CID 39695853.
Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID 10207129.
Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 9780123646002. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. S2CID 205014301.
Fox GM, Holst PL, Chute HT, et al. (1995). "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases". Oncogene. 10 (5): 897–905. PMID 7898931.
Davis S, Gale NW, Aldrich TH, et al. (1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity". Science. 266 (5186): 816–9. Bibcode:1994Sci...266..816D. doi:10.1126/science.7973638. PMID 7973638.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474. S2CID 1075856.
Miescher GC, Taylor V, Olivieri G, et al. (1997). "Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors". Brain Res. Mol. Brain Res. 46 (1–2): 17–24. doi:10.1016/S0169-328X(96)00268-9. PMID 9191074.
Stein E, Savaskan NE, Ninnemann O, et al. (1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting". J. Neurosci. 19 (20): 8885–93. doi:10.1523/JNEUROSCI.19-20-08885.1999. PMC 6782767. PMID 10516308.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145242 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029245 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9267020-5] Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.

[pmid7528718-6] Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics. 22 (2): 431–6. doi:10.1006/geno.1994.1405. PMID 7528718.

[entrez-7] "Entrez Gene: EPHA5 EPH receptor A5".

1

2

3

4

5

6

7