Article · Wikipedia archive · Last revised Jun 20, 2026

EMDA-2

EMDA-2, also known as 2-ethoxy-4,5-methylenedioxyamphetamine, 6-ethoxy-MDA, or 6-ethoxy-MMDA-2, is a psychedelic drug of the phenethylamine and methylenedioxyamphetamine families. It is the analogue of MMDA-2 in which the 2-methoxy group has been replaced with a 2-ethoxy group. This has resulted in EMDA-2 being described as the "TWEETIO" analogue of MMDA-2.

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Jun 20, 2026
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EMDA-2
Clinical data
Other names2-Ethoxy-4,5-methylenedioxyamphetamine; 6-Ethoxy-MDA; 6-EtO-MDA; 6-Ethoxy-MMDA-2; 6-EtO-MMDA-2
Routes of
administration		Oral12
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • 1-(6-ethoxy-1,3-benzodioxol-5-yl)propan-2-amine
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC12H17NO3
Molar mass223.272 g·mol−1
3D model (JSmol)
  • CCOC1=CC2=C(C=C1CC(C)N)OCO2
  • InChI=1S/C12H17NO3/c1-3-14-10-6-12-11(15-7-16-12)5-9(10)4-8(2)13/h5-6,8H,3-4,7,13H2,1-2H3
  • Key:OHOFHHFTTSOJCK-UHFFFAOYSA-N

EMDA-2, also known as 2-ethoxy-4,5-methylenedioxyamphetamine, 6-ethoxy-MDA, or 6-ethoxy-MMDA-2, is a psychedelic drug of the phenethylamine and methylenedioxyamphetamine families.123 It is the analogue of MMDA-2 in which the 2-methoxy group has been replaced with a 2-ethoxy group.12 This has resulted in EMDA-2 being described as the "TWEETIO" analogue of MMDA-2.1

Use and effects

EMDA-2's dose is approximately 135 to 185 mg and its duration is about 10 to 12 hours.12 At 135 mg, it produced closed eye visuals, including intense colors, with sleep disturbances and a duration of some 10 hours.1 At 185 mg, its effects were stronger, including "marvelous" closed-eye visuals with "incredible" colors, good concentration, and distinct body tingles and rushes, with insomnia and a duration of about 12 hours.1 The potency of EMDA-2 is about one-third that of MMDA-2.1

Interactions

History

EMDA-2 appears to have first been described in the scientific literature by at least 1975.3 Its effects in humans were described by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).12

Society and culture

Canada

EMDA-2 may be a controlled substance in Canada under phenethylamine blanket-ban language.4

See also

See also

References

References

  1. Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. "The Tweetio homologue of MMDA-2 has been tasted, however. This is 2-ethoxy-4,5-methylenedioxyamphetamine, or EMDA-2. [...] At 135 milligrams, there have been reported eyes-closed visual phenomena, with intense colors. The overall duration is similar to MMDA-2 (some 10 hours) and there are reported sleep disturbances. At 185 milligrams, the feelings were intensified, there were “marvelous eyes-closed visuals (the colors were incredible), good concentration, but distinct body-tingles and rushes.” The time span was about 12 hours from start to finish, but it proved to be impossible to sleep afterwards. This homologue is thus about a third the potency of MMDA-2."
  2. Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. pp. 828–829. ISBN 978-3-03788-700-4. OCLC 858805226. Retrieved 31 January 2025.
  3. Brimblecombe RW, Pinder RM (1975). "Phenylalkylamines and Their Derivatives". Hallucinogenic Agents. Bristol: Wright-Scientechnica. pp. 55–97.
  4. "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
External links