ELAV-like protein 3

ELAVL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D8Z, 1D9A, 1FNX
Identifiers
Aliases	ELAVL3, HUC, HUCL, PLE21, ELAV like neuron-specific RNA binding protein 3, ELAV like RNA binding protein 3
External IDs	OMIM: 603458; MGI: 109157; HomoloGene: 31035; GeneCards: ELAVL3; OMA:ELAVL3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	11,481,046 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,963,319 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; postcentral gyrus; ; entorhinal cortex; ; ventral tegmental area; ; superior vestibular nucleus; ; ganglionic eminence; ; cerebellar cortex; ; paraflocculus of cerebellum; ; cerebellar vermis; ; pons;
	Top expressed in
	Rostral migratory stream; ; cerebellar cortex; ; lobe of cerebellum; ; cerebellar vermis; ; habenula; ; superior frontal gyrus; ; ganglionic eminence; ; subiculum; ; pontine nuclei; ; medial geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Orthologs
	1995
	15571
	ENSG00000196361
	ENSMUSG00000003410
	Q14576
	Q60900
	NM_001420; NM_032281
	NM_010487
	NP_001411; NP_115657
	NP_034617
	Wikidata
View/Edit Human	View/Edit Mouse

ELAV-like protein 3 is a protein that in humans is encoded by the ELAVL3 gene.⁵⁶

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.⁶

References

GRCh38: Ensembl release 89: ENSG00000196361 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000003410 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH (Dec 1998). "Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique". Genomics. 53 (3): 296–9. doi:10.1006/geno.1998.5468. PMID 9799595.
"Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)".

Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library". Int. J. Cancer. 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604. S2CID 35369661.
Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA". Biochem. Biophys. Res. Commun. 256 (2): 263–8. Bibcode:1999BBRC..256..263S. doi:10.1006/bbrc.1999.0282. PMID 10079173.
Sakai K, Gofuku M, Kitagawa Y, et al. (1994). "A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma". Biochem. Biophys. Res. Commun. 199 (3): 1200–8. Bibcode:1994BBRC..199.1200S. doi:10.1006/bbrc.1994.1358. PMID 7511893.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196361 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003410 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9799595-5] Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH (Dec 1998). "Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique". Genomics. 53 (3): 296–9. doi:10.1006/geno.1998.5468. PMID 9799595.

[entrez-6] "Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)".

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