| Ectoine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.108 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme ectoine synthase (EC 4.2.1.108) catalyzes the chemical reaction which forms the osmoprotectant ectoine in many bacteria, including Halomonas elongata, Bacillus pasteurii and Marinococcus halophilus.1234
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S)-4-acetamido-2-aminobutanoate (L-ectoine-forming). Other names in common use include N-acetyldiaminobutyrate dehydratase, N-acetyldiaminobutanoate dehydratase, L-ectoine synthase, EctC, and 4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming).5
References
References
- Peters P, Galinski EA, Truper HG (1990). "The biosynthesis of ectoine". FEMS Microbiol. Lett. 71 (1–2): 157–162. doi:10.1111/j.1574-6968.1990.tb03815.x.
- Ono H, Sawada K, Khunajakr N, et al. (1999). "Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata". J. Bacteriol. 181 (1): 91–9. doi:10.1128/JB.181.1.91-99.1999. PMC 103536. PMID 9864317.
- Kuhlmann AU, Bremer E (2002). "Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp". Appl. Environ. Microbiol. 68 (2): 772–83. Bibcode:2002ApEnM..68..772K. doi:10.1128/AEM.68.2.772-783.2002. PMC 126723. PMID 11823218.
- Louis P, Galinski EA (1997). "Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halophilus and osmoregulated expression in Escherichia coli". Microbiology. 143 (4): 1141–9. doi:10.1099/00221287-143-4-1141. PMID 9141677.
- Enzyme 4.2.1.108 at KEGG Pathway Database.